4-((4-Methylpiperazin-1-yl)Methyl)phenylboronic acid

Base Information

• Chemical Name: 4-((4-Methylpiperazin-1-yl)Methyl)phenylboronic acid
• CAS No.: 763120-62-3
• Molecular Formula: C12H19BN2O2
• Molecular Weight: 234.106
• Mol file: 763120-62-3.mol

Synonyms:4-((4-Methylpiperazin-1-yl)Methyl)phenylboronic acid;4-((4-ethylpiperazin-1-yl)Methyl)phenylboronic acid

Chemical Property of 4-((4-Methylpiperazin-1-yl)Methyl)phenylboronic acid

Chemical Property:

• PSA: 46.94000
• LogP: 0.59360

Purity/Quality:

97% ^*data from raw suppliers

[4-[(4-Methylpiperazin-1-yl)methyl]phenyl]boronicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: [4-[(4-Methylpiperazin-1-yl)methyl]phenyl]boronic Acid is used to prepare N-(3-(pyrazolo[1,5-a]pyrimidin-7-yl)phenyl)-3-(trifluoromethyl)benzamides as B-Raf kinase inhibitors.

Technology Process of 4-((4-Methylpiperazin-1-yl)Methyl)phenylboronic acid

There total 6 articles about 4-((4-Methylpiperazin-1-yl)Methyl)phenylboronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.3%

4-[(4-methylpiperazin-1-yl)methyl]bromobenzene (368879-17-8) → (4-((4-methylpiperazin-1-yl)methyl)phenyl)boronic acid (763120-62-3)

Guidance literature:

With n-butyllithium; Triisopropyl borate; In tetrahydrofuran; at -78 ℃;

Reference yield:

1-methyl-piperazine (109-01-3) + 4-bromomethylphenylboronic acid (68162-47-0) → (4-((4-methylpiperazin-1-yl)methyl)phenyl)boronic acid (763120-62-3)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃;

Reference yield:

1-methyl-piperazine (109-01-3) + 4-formylphenylboronic acid, (87199-17-5) → (4-((4-methylpiperazin-1-yl)methyl)phenyl)boronic acid (763120-62-3)

Guidance literature:

1-methyl-piperazine; 4-formylphenylboronic acid,; With acetic acid; In tetrahydrofuran; methanol; at 20 ℃; for 1.5h;

With methanol; sodium tris(acetoxy)borohydride; In tetrahydrofuran; at 60 ℃; for 18h;

upstream raw materials:

1-methyl-piperazine

1-bromomethyl-4-bromobenzene

4-[(4-methylpiperazin-1-yl)methyl]bromobenzene

4-bromomethylphenylboronic acid

Downstream raw materials:

4-tert-butyl-6-{5-[4-(4-methyl-piperazin-1-ylmethyl)-phenyl]-pyridin-3-yl}-2-pyridin-2-yl-pyrimidine

5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1H-pyrrolo[2,3-b]pyridine

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