2-(Trifluoroacetyl)-4-(trifluoromethyl)aniline, 1-[2-Amino-5-(trifluoromethyl)phenyl]-2,2,2-trifluoroethan-1-one, 4-Amino-3-(trifluoroacetyl)benzotrifluoride

Base Information

• Chemical Name: 2-(Trifluoroacetyl)-4-(trifluoromethyl)aniline, 1-[2-Amino-5-(trifluoromethyl)phenyl]-2,2,2-trifluoroethan-1-one, 4-Amino-3-(trifluoroacetyl)benzotrifluoride
• CAS No.: 489429-73-4
• Molecular Formula: C₉H₅F₆NO
• Molecular Weight: 257.135
• Hs Code.: 2922399090
• Mol file: 489429-73-4.mol

Synonyms:2-(Trifluoroacetyl)-4-(trifluoromethyl)aniline, 1-[2-Amino-5-(trifluoromethyl)phenyl]-2,2,2-trifluoroethan-1-one, 4-Amino-3-(trifluoroacetyl)benzotrifluoride;2'-Amino-2,2,2-trifluoro-5'-(trifluoromethyl)acetophenone;1-(2-amino-5-(trifluoromethyl)phenyl)-2,2,2-trifluoroethanone

Chemical Property of 2-(Trifluoroacetyl)-4-(trifluoromethyl)aniline, 1-[2-Amino-5-(trifluoromethyl)phenyl]-2,2,2-trifluoroethan-1-one, 4-Amino-3-(trifluoroacetyl)benzotrifluoride

Chemical Property:

• PSA: 43.09000
• LogP: 3.61380

Purity/Quality:

97% ^*data from raw suppliers

2'-Amino-2,2,2-trifluoro-5'-(trifluoromethyl)acetophenone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(Trifluoroacetyl)-4-(trifluoromethyl)aniline, 1-[2-Amino-5-(trifluoromethyl)phenyl]-2,2,2-trifluoroethan-1-one, 4-Amino-3-(trifluoroacetyl)benzotrifluoride

There total 3 articles about 2-(Trifluoroacetyl)-4-(trifluoromethyl)aniline, 1-[2-Amino-5-(trifluoromethyl)phenyl]-2,2,2-trifluoroethan-1-one, 4-Amino-3-(trifluoroacetyl)benzotrifluoride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C14H13F6NO2 (1233967-39-9) → 1-(2-amino-5-(trifluoromethyl)phenyl)-2,2,2-trifluoroethanone (489429-73-4)

Guidance literature:

C₁₄H₁₃F₆NO₂; With hydrogenchloride; water; at 25 - 75 ℃;

With sodium hydrogencarbonate; In water; ethyl acetate;

DOI:10.1016/j.ejmech.2010.02.051

Reference yield:

2,2-dimethyl-N-(4-trifluoromethylphenyl)propanamide (25617-34-9) → 1-(2-amino-5-(trifluoromethyl)phenyl)-2,2,2-trifluoroethanone (489429-73-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: N,N,N,N,-tetramethylethylenediamine; n-butyllithium / tetrahydrofuran; hexane / 2 h / -78 - 0 °C

1.2: 2 h / -20 - 0 °C

2.1: hydrogenchloride / 1,4-dioxane / 12 h / 80 °C

With hydrogenchloride; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; In tetrahydrofuran; 1,4-dioxane; hexane;

DOI:10.1002/chem.201603105

Reference yield:

4-trifluoromethylphenylamine (455-14-1) → 1-(2-amino-5-(trifluoromethyl)phenyl)-2,2,2-trifluoroethanone (489429-73-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 0 - 20 °C

2.1: N,N,N,N,-tetramethylethylenediamine; n-butyllithium / tetrahydrofuran / 4 h / -78 - 0 °C / Inert atmosphere

2.2: 6 h / -78 - 20 °C / Inert atmosphere

3.1: hydrogenchloride / water; tetrahydrofuran / 6 h / 80 °C

With hydrogenchloride; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; triethylamine; In tetrahydrofuran; dichloromethane; water;

DOI:10.1039/d0cc08131k

upstream raw materials:

C₁₄H₁₃F₆NO₂

2,2-dimethyl-N-(4-trifluoromethylphenyl)propanamide

4-trifluoromethylphenylamine

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