Propanamide, 2,2-dimethyl-N-[4-(trifluoromethyl)phenyl]-

Base Information

• Chemical Name: Propanamide, 2,2-dimethyl-N-[4-(trifluoromethyl)phenyl]-
• CAS No.: 25617-34-9
• Molecular Formula: C12H14F3NO
• Molecular Weight: 245.244
• Hs Code.: 2924299090
• Mol file: 25617-34-9.mol

Synonyms:N-(4-trifluoromethylphenyl)-2,2-dimethylpropanamide;2,2-dimethyl-N-(4-trifluoromethylphenyl)propionamide;N-(4-(trifluoromethyl)phenyl)pivalamide;N-[4-(Trifluoromethyl)phenyl]-trimethylacetamide;4-trifluoromethyl-N-pivaloylaniline;

Chemical Property of Propanamide, 2,2-dimethyl-N-[4-(trifluoromethyl)phenyl]-

Chemical Property:

• PSA: 29.10000
• LogP: 3.76300

Purity/Quality:

99% ^*data from raw suppliers

N-(2,2-Dimethylpropanoyl)-4-(trifluoromethyl)aniline 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Propanamide, 2,2-dimethyl-N-[4-(trifluoromethyl)phenyl]-

There total 16 articles about Propanamide, 2,2-dimethyl-N-[4-(trifluoromethyl)phenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-trifluoromethylphenylamine (455-14-1) + pivaloyl chloride (3282-30-2) → 2,2-dimethyl-N-(4-trifluoromethylphenyl)propanamide (25617-34-9)

Guidance literature:

With triethylamine; In dichloromethane;

Reference yield: 96.0%

4-trifluoromethylphenylamine (455-14-1) + Methyl pivalate (598-98-1) → 2,2-dimethyl-N-(4-trifluoromethylphenyl)propanamide (25617-34-9)

Guidance literature:

With sodium hexamethyldisilazane; In tetrahydrofuran; at 0 - 20 ℃; for 2h;

DOI:10.1055/s-2001-16798

Reference yield: 88.0%

cesium pivalate + p-trifluoromethyl-phenylisocyanate (1548-13-6) → 2,2-dimethyl-N-(4-trifluoromethylphenyl)propanamide (25617-34-9)

Guidance literature:

In N,N-dimethyl-formamide; at 25 ℃; for 2h;

DOI:10.1021/ol200531k

upstream raw materials:

4-trifluoromethylphenylamine

pivaloyl chloride

Methyl pivalate

sodium hydrogencarbonate

Downstream raw materials:

N-(2-Hydroxymethyl-4-trifluoromethyl-phenyl)-2,2-dimethyl-propionamide

2-(chloromethyl)-4-(trifluoromethyl)aniline hydrochloride

N-[2-formyl-4-(trifluoromethyl)-phenyl]-2,2-dimethyl propanamide

2'-[α-Hydroxy-(1-naphthyl)methyl]-4'-trifluoromethyl-2,2-dimethylpropionanilide