(6aR-trans)-1-[(tert-Butyl)diMethylsilyloxy]-6a,7,8

Base Information

Chemical Name:(6aR-trans)-1-[(tert-Butyl)diMethylsilyloxy]-6a,7,8
CAS No.:138285-36-6
Molecular Formula:C27H42O3Si
Molecular Weight:442.714
Hs Code.:
Mol file:138285-36-6.mol

Synonyms:(6aR-trans)-1-[[(1,1-DiMethylethyl)diMethylsilyl]oxy]-6a,7,8,10a-tetrahydro-6,6-diMethyl-3-pentyl-6H-dibenzo[b,d]pyran-9-carboxylate;1-O-[(tert-Butyl)diMethylsilyloxy]-9-forMyl-9-tetrahydro Cannabinol

Suppliers and Price of (6aR-trans)-1-[(tert-Butyl)diMethylsilyloxy]-6a,7,8

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Biosynth Carbosynth
1-O-[(tert-Butyl)dimethylsilyloxy]-9-formyl-delta9-tetrahydro cannabinol
10 mg
$ 1365.00

Biosynth Carbosynth
1-O-[(tert-Butyl)dimethylsilyloxy]-9-formyl-delta9-tetrahydro cannabinol
5 mg
$ 750.80

Biosynth Carbosynth
1-O-[(tert-Butyl)dimethylsilyloxy]-9-formyl-delta9-tetrahydro cannabinol
2 mg
$ 413.00

Biosynth Carbosynth
1-O-[(tert-Butyl)dimethylsilyloxy]-9-formyl-delta9-tetrahydro cannabinol
1 mg
$ 227.20

Total 1 raw suppliers

Chemical Property of (6aR-trans)-1-[(tert-Butyl)diMethylsilyloxy]-6a,7,8

Chemical Property:

PSA：35.53000
LogP:7.59320

Purity/Quality:: 1-O-[(tert-Butyl)dimethylsilyloxy]-9-formyl-delta9-tetrahydro cannabinol ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses (6aR,10aR)-1-[tert-butyl(dimethyl)silyl]oxy-6,6-dimethyl-3-pentyl-6a,7,8,10a-tetrahydrobenzo[c]chromene-9-carbaldehyde is used in the preparation of a major Tetrahydrocannabinol (T293200) metabolite.

Technology Process of (6aR-trans)-1-[(tert-Butyl)diMethylsilyloxy]-6a,7,8

There total 8 articles about (6aR-trans)-1-[(tert-Butyl)diMethylsilyloxy]-6a,7,8 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 136954-90-0
(+/-)-9-normethyl-9-(1,3-dithianyl)-Δ⁹-tetrahydrocannabiol tert-butyldimethylsilyl ether

: 136954-91-1,138285-36-6
(+/-)-11-oxo-Δ⁹-tetrahydrocannabiol tert-butyldimethylsilyl ether

Guidance literature:: With potassium carbonate; methyl iodide; In water; N,N-dimethyl-formamide; for 5h; Ambient temperature;
DOI:10.1021/jo00024a031

Reference yield: 52.0%

: 52663-85-1,67145-57-7
11-oxo-6a,10a-trans-Δ⁹-THC

: 18162-48-6
tert-butyldimethylsilyl chloride

: 136954-91-1,138285-36-6
(+/-)-11-oxo-Δ⁹-tetrahydrocannabiol tert-butyldimethylsilyl ether

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; for 8h; Ambient temperature;
DOI:10.1055/s-1991-26590

Reference yield:

: 67119-85-1
(+/-)-4-(1-hydroxy-1-methylethyl)cyclohex-2-enone

: 136954-91-1,138285-36-6
(+/-)-11-oxo-Δ⁹-tetrahydrocannabiol tert-butyldimethylsilyl ether

Guidance literature:: Multi-step reaction with 4 steps

1: 1) n-BuLi / 1) THF, hexane, -30 deg C, 1.5 h, 2) THF, room temperature, 0.5 h

2: 19 percent / p-TosOH*H₂O / benzene / 0.25 h / 85 - 90 °C

3: 61 percent / imidazole / dimethylformamide / 16 h / Ambient temperature

4: 60 percent / CH₃I, K₂CO₃ / dimethylformamide; H₂O / 5 h / Ambient temperature

With 1H-imidazole; n-butyllithium; potassium carbonate; toluene-4-sulfonic acid; methyl iodide; In water; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jo00024a031