1-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-2-(6-methylpyridin-2-yl)ethane-1,2-dione

Base Information

• Chemical Name: 1-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-2-(6-methylpyridin-2-yl)ethane-1,2-dione
• CAS No.: 356560-84-4
• Molecular Formula: C14H10N4O2
• Molecular Weight: 266.259
• Hs Code.: 2933990090
• Mol file: 356560-84-4.mol

Synonyms:1-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-2-(6-methylpyridin-2-yl)ethane-1,2-dione;QC-1211;1-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-2-(6-methylpyridin-2-yl);

Chemical Property of 1-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-2-(6-methylpyridin-2-yl)ethane-1,2-dione

Chemical Property:

• PKA: 0.85±0.10(Predicted)
• PSA: 77.22000
• Density: 1.39±0.1 g/cm3(Predicted)
• LogP: 1.49830
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

1-([1,2,4]Triazolo[1,5-a]pyridin-6-yl)-2-(6-methylpyridin-2-yl)ethane-1,2-dione 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-2-(6-methylpyridin-2-yl)ethane-1,2-dione can be used as an intermediate in organic synthesis and pharmaceutical intermediates, mainly used in laboratory research and development processes and chemical production processes.

Technology Process of 1-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-2-(6-methylpyridin-2-yl)ethane-1,2-dione

There total 3 articles about 1-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-2-(6-methylpyridin-2-yl)ethane-1,2-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

1-(6-methylpyridin-2-yl)-2-[1,2,4]triazolo-[1,5-a]pyridin-6-yl-ethanone (614750-82-2) → 1-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-2-(6-methylpyridin-2-yl)ethane-1,2-dione (356560-84-4)

Guidance literature:

With hydrogen bromide; dimethyl sulfoxide; at 60 - 70 ℃; for 2h;

Reference yield:

6-methyl-2-pyridinecarboxaldehyde (1122-72-1) → 1-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-2-(6-methylpyridin-2-yl)ethane-1,2-dione (356560-84-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: ziconium(IV) oxychloride octahydrate / 1 h / 20 °C

2.1: caesium carbonate / isopropyl alcohol; tetrahydrofuran / 20 °C

2.2: 1 h

2.3: pH 7 - 8

3.1: dimethyl sulfoxide; hydrogen bromide / 2 h / 60 - 70 °C

With ziconium(IV) oxychloride octahydrate; hydrogen bromide; caesium carbonate; dimethyl sulfoxide; In tetrahydrofuran; isopropyl alcohol;

Reference yield:

diphenyl (6-methylpyridin-2-yl)(phenylamino)methylphosphonate (614750-85-5) → 1-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-2-(6-methylpyridin-2-yl)ethane-1,2-dione (356560-84-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: caesium carbonate / isopropyl alcohol; tetrahydrofuran / 20 °C

1.2: 1 h

1.3: pH 7 - 8

2.1: dimethyl sulfoxide; hydrogen bromide / 2 h / 60 - 70 °C

With hydrogen bromide; caesium carbonate; dimethyl sulfoxide; In tetrahydrofuran; isopropyl alcohol;

upstream raw materials:

1-(6-methylpyridin-2-yl)-2-[1,2,4]triazolo-[1,5-a]pyridin-6-yl-ethanone

6-methyl-2-pyridinecarboxaldehyde

diphenyl (6-methylpyridin-2-yl)(phenylamino)methylphosphonate

Downstream raw materials:

6-(2-(dimethoxymethyl)-5-(6-methylpyridin-2-yl)-1H-imidazol-4-yl)-[1,2,4]triazolo[1,5-a]pyridine

3-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)benzonitrile

6-(5-(6-methylpyridin-2-yl)-2-(phenoxymethyl)-1H-imidazol-4-yl)-[1,2,4]triazolo[1,5-a]pyridine

6-(5-(6-methylpyridin-2-yl)-2-((phenylthio)methyl)-1H-imidazol-4-yl)-[1,2,4]triazolo[1,5-a]pyridine

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