LY3023414

Base Information

Chemical Name:LY3023414
CAS No.:1386874-06-1
Molecular Formula:C23H26N4O3
Molecular Weight:406.48
Hs Code.:
Mol file:1386874-06-1.mol

Synonyms:LY3023414;8-[5-(1-hydroxy-1-methylethyl)pyridin-3-yl]-1-[(2S)-2-methoxypropyl]-3-methyl-1,3-dihydro-2H-imidazo[4,5-c]quinolin-2-one

Suppliers and Price of LY3023414

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
LY3023414 >98%
1 g
$ 1900.00

DC Chemicals
LY3023414 >98%
250 mg
$ 950.00

DC Chemicals
LY3023414 >98%
100 mg
$ 550.00

Crysdot
LY3023414 98+%
10mg
$ 347.00

Crysdot
LY3023414 98+%
100mg
$ 1459.00

Crysdot
LY3023414 98+%
50mg
$ 1042.00

Crysdot
LY3023414 98+%
5mg
$ 243.00

ChemScene
Samotolisib 99.77%
5mg
$ 80.00

ApexBio Technology
LY3023414
5mg
$ 105.00

ApexBio Technology
LY3023414
25mg
$ 345.00

Total 10 raw suppliers

Chemical Property of LY3023414

Chemical Property:

Boiling Point:591.7±50.0 °C(Predicted)
PKA:13.65±0.29(Predicted)
PSA：82.17000
Density:1.239±0.06 g/cm3(Predicted)
LogP:3.21250
Solubility.:≥40.6 mg/mL in DMSO; insoluble in H2O; ≥28.9 mg/mL in EtOH

Purity/Quality:

99%, ^*data from raw suppliers

LY3023414 >98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of LY3023414

There total 14 articles about LY3023414 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.8%

: 1386874-21-0
ethyl 5-[1-[(2S)-2-methoxypropyl]-3-methyl-2-oxo-imidazo[4,5-c]quinolin-8-yl]pyridine-3-carboxylate

: 75-16-1
methylmagnesium bromide

: 1386874-06-1
LY3023414

Guidance literature:: ethyl 5-[1-[(2S)-2-methoxypropyl]-3-methyl-2-oxo-imidazo[4,5-c]quinolin-8-yl]pyridine-3-carboxylate; methylmagnesium bromide; In tetrahydrofuran; toluene; at -5 - 0 ℃; for 1h; Inert atmosphere;

With water; ammonium chloride; In tetrahydrofuran; ethyl acetate; toluene; at 25 - 30 ℃; for 0.5h;

Reference yield: 51.0%

: 40472-88-6
3-bromo-5-(hydroxyisopropyl)pyridine

: 1386874-33-4
8-bromo-1-[(2S)-2-methoxypropyl]-3-methyl-imidazo[4,5-c]quinolin-2-one

: 1386874-06-1
LY3023414

Guidance literature:: 3-bromo-5-(hydroxyisopropyl)pyridine; With potassium acetate; bis(pinacol)diborane; 1,1'-bis(diphenylphosphino)ferrocene-palladium(II)dichloride dichloromethane complex; In 1,4-dioxane; at 20 - 80 ℃; for 3.5h; Inert atmosphere;

8-bromo-1-[(2S)-2-methoxypropyl]-3-methyl-imidazo[4,5-c]quinolin-2-one; With sodium carbonate; In 1,4-dioxane; water; at 90 ℃; for 1.5h;

Reference yield: 44.0%

: 1257431-63-2
2-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)propan-2-ol

: 1386874-33-4
8-bromo-1-[(2S)-2-methoxypropyl]-3-methyl-imidazo[4,5-c]quinolin-2-one

: 1386874-06-1
LY3023414

Guidance literature:: With potassium fluoride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri tert-butylphosphoniumtetrafluoroborate; In tetrahydrofuran; water; at 65 - 70 ℃; Inert atmosphere; Sealed tube;