4-Morpholineacetamide, N-(5-ethyl-2-methylphenyl)-

Base Information

• Chemical Name: 4-Morpholineacetamide, N-(5-ethyl-2-methylphenyl)-
• CAS No.: 671-06-7
• Molecular Formula: C15H22N2O2
• Molecular Weight: 262.3474
• DSSTox Substance ID: DTXSID70986125
• Wikidata: Q82973918
• Mol file: 671-06-7.mol

Synonyms:671-06-7;BRN 0231349;4-Morpholineaceto-o-toluidide, 5'-ethyl-;5'-Ethyl-2'-methyl-4-morpholineacetanilide;4-Morpholineacetamide, N-(5-ethyl-2-methylphenyl)-;alpha-Morpholino-3-aethyl-6-methyl-acetanilid [German];DTXSID70986125;A9096;alpha-Morpholino-3-aethyl-6-methyl-acetanilid;4-27-00-00318 (Beilstein Handbook Reference);N-(5-Ethyl-2-methylphenyl)-2-(morpholin-4-yl)ethanimidic acid

Chemical Property of 4-Morpholineacetamide, N-(5-ethyl-2-methylphenyl)-

Chemical Property:

• Vapor Pressure: 2.65E-07mmHg at 25°C
• Melting Point: 115 °C
• Boiling Point: 421.2°Cat760mmHg
• PKA: 14.48±0.70(Predicted)
• Flash Point: 208.5°C
• PSA: 0.00000
• Density: 1.11g/cm³
• LogP: 0.00000
• XLogP3: 2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 262.168127949
• Heavy Atom Count: 19
• Complexity: 290

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CCC1=CC(=C(C=C1)C)NC(=O)CN2CCOCC2

Technology Process of 4-Morpholineacetamide, N-(5-ethyl-2-methylphenyl)-

There total 4 articles about 4-Morpholineacetamide, N-(5-ethyl-2-methylphenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

morpholino-acetic acid-(5-acetyl-2-methyl-anilide) (109840-45-1) → N-Morpholinoacetyl-2-methyl-5-ethyl-anilin (671-06-7)

Guidance literature:

With sulfuric acid; palladium; acetic acid; Hydrogenation;

Reference yield:

1-(4-methyl-3-nitro-phenyl)-ethanone (5333-27-7) → N-Morpholinoacetyl-2-methyl-5-ethyl-anilin (671-06-7)

Guidance literature:

Multi-step reaction with 3 steps

1: palladium; benzene / Hydrogenation

2: NaHCO₃; acetone / anschliessend Erwaermen mit Morpholin in Toluol

3: palladium; H₂SO₄; acetic acid / Hydrogenation

With sulfuric acid; sodium hydrogencarbonate; palladium; acetic acid; acetone; benzene;

Reference yield:

1-(3-amino-4-methylphenyl)ethanone (17071-24-8) → N-Morpholinoacetyl-2-methyl-5-ethyl-anilin (671-06-7)

Guidance literature:

Multi-step reaction with 2 steps

1: NaHCO₃; acetone / anschliessend Erwaermen mit Morpholin in Toluol

2: palladium; H₂SO₄; acetic acid / Hydrogenation

With sulfuric acid; sodium hydrogencarbonate; palladium; acetic acid; acetone;

upstream raw materials:

morpholino-acetic acid-(5-acetyl-2-methyl-anilide)

morpholine

5-ethyl-2-methylphenylamine

chloroacetyl chloride