17071-24-8Relevant articles and documents
Tariquidar-Related Chalcones and Ketones as ABCG2 Modulators
Pe?a-Solórzano, Diana,Scholler, Matthias,Bernhardt, Günther,Buschauer, Armin,K?nig, Burkhard,Ochoa-Puentes, Cristian
, p. 854 - 859 (2018)
ABC transporters, including ABCG2, play a vital role in defending the human body against the vast range of xenobiotics. Even though this is beneficial for human health, these protein transporters have been implicated in the emerging resistance of cancer c
THIAZOLIDINONE COMPOUNDS AND USE THEREOF
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Paragraph 0243-0244, (2017/09/21)
A pharmaceutical composition containing a compound of Formula (I) for treating an opioid receptor-associated condition. Also disclosed is a method for treating an opioid receptor-associated condition using such a compound. Further disclosed are two sets of thiazolidinone compounds of formula (I): (i) compounds each having an enantiomeric excess greater than 90% and (ii) compounds each being substituted with deuterium.
Fragment-Based Discovery of Potent and Selective DDR1/2 Inhibitors
Murray, Christopher W.,Berdini, Valerio,Buck, Ildiko M.,Carr, Maria E.,Cleasby, Anne,Coyle, Joseph E.,Curry, Jayne E.,Day, James E. H.,Day, Phillip J.,Hearn, Keisha,Iqbal, Aman,Lee, Lydia Y. W.,Martins, Vanessa,Mortenson, Paul N.,Munck, Joanne M.,Page, Lee W.,Patel, Sahil,Roomans, Susan,Smith, Kirsten,Tamanini, Emiliano,Saxty, Gordon
supporting information, p. 798 - 803 (2015/07/15)
The DDR1 and DDR2 receptor tyrosine kinases are activated by extracellular collagen and have been implicated in a number of human diseases including cancer. We performed a fragment-based screen against DDR1 and identified fragments that bound either at th