CEP-37440

Base Information

Chemical Name:CEP-37440
CAS No.:1391712-60-9
Molecular Formula:C30H38ClN7O3
Molecular Weight:580.13
Hs Code.:
Mol file:1391712-60-9.mol

Synonyms:CEP-37440;2-[[5-Chloro-2-[[(6S)-6,7,8,9-tetrahydro-6-[4-(2-hydroxyethyl)-1-piperazinyl]-1-methoxy-5H-benzocyclohepten-2-yl]amino]-4-pyrimidinyl]amino]-N-methylbenzamide

Suppliers and Price of CEP-37440

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
CEP-37440
5mg
$ 520.00

DC Chemicals
CEP-37440 >98%
100 mg
$ 550.00

DC Chemicals
CEP-37440 >98%
250 mg
$ 1100.00

Crysdot
CEP-37440 98+%
50mg
$ 253.00

Crysdot
CEP-37440 98+%
100mg
$ 380.00

ChemScene
CEP-37440 99.97%
100mg
$ 1023.00

ChemScene
CEP-37440 99.97%
50mg
$ 630.00

ChemScene
CEP-37440 99.97%
5mg
$ 90.00

ChemScene
CEP-37440 99.97%
10mg
$ 160.00

Cayman Chemical
CEP-37440 ≥98%
25mg
$ 375.00

Total 14 raw suppliers

Chemical Property of CEP-37440

Chemical Property:

PSA：114.88000
LogP:4.25540
Storage Temp.:2-8°C(protect from light)

Purity/Quality:

99%, ^*data from raw suppliers

CEP-37440 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses CEP-37440 is a highly potent, selective and orally active inhibitor of ALK.

Technology Process of CEP-37440

There total 16 articles about CEP-37440 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 761440-08-8
2-[(2,5-dichloropyrimidin-4-yl)amino]-N-methyl-benzamide

: 2-[4-[(6S)-2-amino-1-methoxy-6,7,8,9-tetrahydro-5H-benzo[7]annulen-6-yl]piperazin-1-yl]ethanol L-tartrate salt

: 1391712-60-9
2-[[5-chloro-2-[[(6S)-6-[4-(2-hydroxyethyl)piperazin-1-yl]-1-methoxy-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-yl]-amino]pyrimidin-4-yl]amino]-N-methylbenzamide

Guidance literature:: 2-[4-[(6S)-2-amino-1-methoxy-6,7,8,9-tetrahydro-5H-benzo[7]annulen-6-yl]piperazin-1-yl]ethanol L-tartrate salt; With sodium hydroxide; In dichloromethane; water; at 25 ℃; for 0.5h; Large scale;

2-[(2,5-dichloropyrimidin-4-yl)amino]-N-methyl-benzamide; With methanesulfonic acid; at 70 ℃; for 45h; Large scale;
DOI:10.1021/acs.oprd.7b00070

Reference yield: 28.0%

: 761440-08-8
2-[(2,5-dichloropyrimidin-4-yl)amino]-N-methyl-benzamide

: 1454651-63-8
2-[4-((S)-2-amino-1-methoxy-6,7,8,9-tetrahydro-5H-benzocyclohepten-6-yl)piperazin-1-yl]ethanol

: 1391712-60-9
2-[[5-chloro-2-[[(6S)-6-[4-(2-hydroxyethyl)piperazin-1-yl]-1-methoxy-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-yl]-amino]pyrimidin-4-yl]amino]-N-methylbenzamide

Guidance literature:: With methanesulfonic acid; 1-methoxy-2-propanol; at 90 ℃; for 18h;

Reference yield:

: 33892-75-0
5-Methoxy-1-tetralone

: 1391712-60-9
2-[[5-chloro-2-[[(6S)-6-[4-(2-hydroxyethyl)piperazin-1-yl]-1-methoxy-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-yl]-amino]pyrimidin-4-yl]amino]-N-methylbenzamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium tert-butylate / tetrahydrofuran / 1 h / 20 °C

2.1: thallium(III) nitrate trihydrate / methanol

3.1: potassium nitrate; trifluoroacetic anhydride / acetonitrile / 2.5 h / 0 - 20 °C

4.1: acetic acid / dichloromethane / 2 h / 50 °C

4.2: 0 - 20 °C

5.1: hydrogen; palladium 10% on activated carbon / ethanol / 3 - 4 h / 2585.81 Torr

6.1: Chiralcel OJ-H / Resolution of racemate

7.1: 1-methoxy-2-propanol; methanesulfonic acid / 18 h / 90 °C

With methanesulfonic acid; thallium(III) nitrate trihydrate; 1-methoxy-2-propanol; palladium 10% on activated carbon; potassium tert-butylate; hydrogen; acetic acid; potassium nitrate; trifluoroacetic anhydride; In tetrahydrofuran; methanol; ethanol; dichloromethane; acetonitrile;