2-(4-(2-amino-1-methoxy-6,7,8,9-tetrahydro-5H-benzo[7]annulen-6-yl)piperazin-1-yl)ethanol

Base Information

Chemical Name:2-(4-(2-amino-1-methoxy-6,7,8,9-tetrahydro-5H-benzo[7]annulen-6-yl)piperazin-1-yl)ethanol
CAS No.:1454651-62-7
Molecular Formula:C₁₈H₂₉N₃O₂
Molecular Weight:319.447
Hs Code.:

Synonyms:2-[4-(2-amino-1-methoxy-6,7,8,9-tetrahydro-5H-benzocyclohepten-6-yl)piperazin-1-yl]ethanol

Suppliers and Price of 2-(4-(2-amino-1-methoxy-6,7,8,9-tetrahydro-5H-benzo[7]annulen-6-yl)piperazin-1-yl)ethanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 5 raw suppliers

Chemical Property of 2-(4-(2-amino-1-methoxy-6,7,8,9-tetrahydro-5H-benzo[7]annulen-6-yl)piperazin-1-yl)ethanol

Chemical Property:

Boiling Point:525.8±50.0 °C(Predicted)
PKA:14.96±0.10(Predicted)
Density:1.150±0.06 g/cm3(Predicted)

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

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Technology Process of 2-(4-(2-amino-1-methoxy-6,7,8,9-tetrahydro-5H-benzo[7]annulen-6-yl)piperazin-1-yl)ethanol

There total 8 articles about 2-(4-(2-amino-1-methoxy-6,7,8,9-tetrahydro-5H-benzo[7]annulen-6-yl)piperazin-1-yl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1454651-61-6
2-[4-(1-methoxy-2-nitro-6,7,8,9-tetrahydro-5H-benzocyclohepten-6-yl)piperazin-1-yl]ethanol

: 1454651-62-7
2-[4-(2-amino-1-methoxy-6,7,8,9-tetrahydro-5H-benzocyclohepten-6-yl)piperazin-1-yl]ethanol

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In ethanol; for 3 - 4h; under 2585.81 Torr;

Reference yield: 80.0%

: 103-76-4
1-(2-hydroxyethyl)piperazine

: 4-chloro-1-methoxy-2-nitro-5,7,8,9-tetrahydrobenzo[7]annulen-6-one

: 1454651-62-7
2-[4-(2-amino-1-methoxy-6,7,8,9-tetrahydro-5H-benzocyclohepten-6-yl)piperazin-1-yl]ethanol

Guidance literature:: With 5%-palladium/activated carbon; hydrogen; In methanol; at 15 - 80 ℃; for 24h; under 775.743 Torr; Reagent/catalyst; Large scale;
DOI:10.1021/acs.oprd.7b00070

Reference yield:

: 33892-75-0
5-Methoxy-1-tetralone

: 1454651-62-7
2-[4-(2-amino-1-methoxy-6,7,8,9-tetrahydro-5H-benzocyclohepten-6-yl)piperazin-1-yl]ethanol

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium tert-butylate / tetrahydrofuran / 1 h / 20 °C

2.1: thallium(III) nitrate trihydrate / methanol

3.1: potassium nitrate; trifluoroacetic anhydride / acetonitrile / 2.5 h / 0 - 20 °C

4.1: acetic acid / dichloromethane / 2 h / 50 °C

4.2: 0 - 20 °C

5.1: hydrogen; palladium 10% on activated carbon / ethanol / 3 - 4 h / 2585.81 Torr

With thallium(III) nitrate trihydrate; palladium 10% on activated carbon; potassium tert-butylate; hydrogen; acetic acid; potassium nitrate; trifluoroacetic anhydride; In tetrahydrofuran; methanol; ethanol; dichloromethane; acetonitrile;