6-N-BIOTINYLAMINOHEXYL HYDROGENPHOSPHONATE

Base Information

• Chemical Name: 6-N-BIOTINYLAMINOHEXYL HYDROGENPHOSPHONATE
• CAS No.: 224583-35-1
• Molecular Formula: C16H30N3O6PS
• Molecular Weight: 423.46
• Mol file: 224583-35-1.mol

Synonyms:6-N-BIOTINYLAMINOHEXYL HYDROGENPHOSPHONATE;(3aS,4S,6aR)-Hexahydro-N-[6-[(hydroxyphosphinyl)oxy]hexyl]-2-oxo-1H-thieno[3,4-d]iMidazole-4-pentanaMide

Chemical Property of 6-N-BIOTINYLAMINOHEXYL HYDROGENPHOSPHONATE

Chemical Property:

• PSA: 165.53000
• LogP: 2.83590

Purity/Quality:

97% ^*data from raw suppliers

6-N-Biotinylaminohexyl hydrogenphosphonate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-N-BIOTINYLAMINOHEXYL HYDROGENPHOSPHONATE

There total 3 articles about 6-N-BIOTINYLAMINOHEXYL HYDROGENPHOSPHONATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

6-N-Biotinylaminohexanol (106451-92-7) → 6-N-Biotinylaminohexyl hydrogenphosphonate (224583-35-1)

Guidance literature:

With pyridine; 2-Chloro-4H-1,3,2-benzodioxaphosphorin-4-one; triethylamine carbonate; In N,N-dimethyl-formamide; for 0.25h;

DOI:10.1055/s-1999-3419

Reference yield:

6-amino-1-hexanol (4048-33-3) → 6-N-Biotinylaminohexyl hydrogenphosphonate (224583-35-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / dimethylsulfoxide / 16 h

2: 94 percent / pyridine, salicyl chlorophosphite, triethylammnonium bicarbonate / dimethylformamide / 0.25 h

With pyridine; 2-Chloro-4H-1,3,2-benzodioxaphosphorin-4-one; triethylamine carbonate; In dimethyl sulfoxide; N,N-dimethyl-formamide;

DOI:10.1055/s-1999-3419

Reference yield:

D-(+)-biotin 2-nitrophenyl ester (33755-53-2) → 6-N-Biotinylaminohexyl hydrogenphosphonate (224583-35-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / dimethylsulfoxide / 16 h

2: 94 percent / pyridine, salicyl chlorophosphite, triethylammnonium bicarbonate / dimethylformamide / 0.25 h

With pyridine; 2-Chloro-4H-1,3,2-benzodioxaphosphorin-4-one; triethylamine carbonate; In dimethyl sulfoxide; N,N-dimethyl-formamide;

DOI:10.1055/s-1999-3419

upstream raw materials:

6-N-Biotinylaminohexanol

6-amino-1-hexanol

D-(+)-biotin 2-nitrophenyl ester

Downstream raw materials:

6-N-Biotinylaminohexyl isopropyl hydrogenphosphonate