6-N-BIOTINYLAMINOHEXYL ISOPROPYL HYDROGENPHOSPHONATE

Base Information

• Chemical Name: 6-N-BIOTINYLAMINOHEXYL ISOPROPYL HYDROGENPHOSPHONATE
• CAS No.: 224583-37-3
• Molecular Formula: C₁₉H₃₆N₃O₅PS
• Molecular Weight: 449.552
• Mol file: 224583-37-3.mol

Synonyms:6-N-BIOTINYLAMINOHEXYL ISOPROPYL HYDROGENPHOSPHONATE;Phosphonic Acid 6-[[5-[(3aS,4S,6aR)-Hexahydro-2-oxo-1H-thieno[3,4-d]iMidazol-4-yl]-1-oxopentyl]aMino]hexyl 1-Methylethyl Ester

Chemical Property of 6-N-BIOTINYLAMINOHEXYL ISOPROPYL HYDROGENPHOSPHONATE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 711.031°C at 760 mmHg
• Flash Point: 383.818°C
• PSA: 154.53000
• LogP: 4.26860

Purity/Quality:

97% ^*data from raw suppliers

6-N-Biotinylaminohexyl isopropyl hydrogenphosphonate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-N-BIOTINYLAMINOHEXYL ISOPROPYL HYDROGENPHOSPHONATE

There total 4 articles about 6-N-BIOTINYLAMINOHEXYL ISOPROPYL HYDROGENPHOSPHONATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

isopropyl alcohol (67-63-0,8013-70-5) + 6-N-Biotinylaminohexyl hydrogenphosphonate (224583-35-1) → 6-N-Biotinylaminohexyl isopropyl hydrogenphosphonate (224583-37-3)

Guidance literature:

With pivaloyl chloride; triethylamine; In N,N-dimethyl-formamide; for 0.333333h;

DOI:10.1055/s-1999-3419

Reference yield:

6-amino-1-hexanol (4048-33-3) → 6-N-Biotinylaminohexyl isopropyl hydrogenphosphonate (224583-37-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 85 percent / dimethylsulfoxide / 16 h

2: 94 percent / pyridine, salicyl chlorophosphite, triethylammnonium bicarbonate / dimethylformamide / 0.25 h

3: 71 percent / Et₃N, pivaloyl chloride / dimethylformamide / 0.33 h

With pyridine; 2-Chloro-4H-1,3,2-benzodioxaphosphorin-4-one; triethylamine carbonate; pivaloyl chloride; triethylamine; In dimethyl sulfoxide; N,N-dimethyl-formamide;

DOI:10.1055/s-1999-3419

Reference yield:

D-(+)-biotin 2-nitrophenyl ester (33755-53-2) → 6-N-Biotinylaminohexyl isopropyl hydrogenphosphonate (224583-37-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 85 percent / dimethylsulfoxide / 16 h

2: 94 percent / pyridine, salicyl chlorophosphite, triethylammnonium bicarbonate / dimethylformamide / 0.25 h

3: 71 percent / Et₃N, pivaloyl chloride / dimethylformamide / 0.33 h

With pyridine; 2-Chloro-4H-1,3,2-benzodioxaphosphorin-4-one; triethylamine carbonate; pivaloyl chloride; triethylamine; In dimethyl sulfoxide; N,N-dimethyl-formamide;

DOI:10.1055/s-1999-3419

upstream raw materials:

isopropyl alcohol

6-N-Biotinylaminohexyl hydrogenphosphonate

6-amino-1-hexanol

D-(+)-biotin 2-nitrophenyl ester

Refernces