5-cyclopropylnicotinonitrile

Base Information

• Chemical Name: 5-cyclopropylnicotinonitrile
• CAS No.: 900802-81-5
• Molecular Formula: C₉H₈N₂
• Molecular Weight: 144.176
• Hs Code.: 2933399090
• Mol file: 900802-81-5.mol

Synonyms:5-cyclopropylnicotinonitrile

Chemical Property of 5-cyclopropylnicotinonitrile

Chemical Property:

• PSA: 36.68000
• LogP: 1.83068
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

5-Cyclopropylnicotinonitrile 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-cyclopropylnicotinonitrile

There total 3 articles about 5-cyclopropylnicotinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

5-bromopyridine-3-carbonitrile (35590-37-5) + cyclopropylboronic acid (411235-57-9) → 5-cyclopropylnicotinonitrile (900802-81-5)

Guidance literature:

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; palladium diacetate; In tetrahydrofuran; for 16h; Inert atmosphere; Reflux;

Reference yield: 23.0%

5-bromopyridine-3-carbonitrile (35590-37-5) + potassium cyclopropyltrifluoroborate (1065010-87-8) → 5-cyclopropylnicotinonitrile (900802-81-5)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate; In 1,4-dioxane; water; at 100 ℃; for 4h; Inert atmosphere;

Reference yield:

5-bromopyridine-3-carbonitrile (35590-37-5) + cyclopropylmagnesium bromide (23719-80-4) → 5-cyclopropylnicotinonitrile (900802-81-5)

Guidance literature:

cyclopropylmagnesium bromide; With zinc(II) chloride; In tetrahydrofuran; at 20 ℃; for 0.5h;

5-bromopyridine-3-carbonitrile; 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; at 85 ℃; for 12.0833h;

upstream raw materials:

5-bromopyridine-3-carbonitrile

cyclopropylboronic acid

cyclopropylmagnesium bromide

potassium cyclopropyltrifluoroborate

Downstream raw materials:

C-(5-cyclopropyl-pyridin-3-yl)-methylamine

Refernces

• 1、 -. "DIACYLGLYCEROL ACYLTRANSFERASE 2 INHIBITORS". Page/Page column 99. . Retrieved 2013/10/22.
• 2、 -. "2-HYDROXY-2-PHENYL/THIOPHENYL PROPIONAMIDES AS ANDROGEN RECEPTOR MODULATORS". Page/Page column 40. . Retrieved 2008/12/05.