N-diphenylphosphoryl-N-propan-2-ylpropan-2-amine

Base Information

• Chemical Name: N-diphenylphosphoryl-N-propan-2-ylpropan-2-amine
• CAS No.: 131173-04-1
• Molecular Formula: C₁₈H₂₄NOP
• Molecular Weight: 301.368
• European Community (EC) Number: 687-514-4
• DSSTox Substance ID: DTXSID90395533
• Nikkaji Number: J2.710.174G
• Wikidata: Q82195671
• Mol file: 131173-04-1.mol

Synonyms:131173-04-1;N-diphenylphosphoryl-N-propan-2-ylpropan-2-amine;STK377126;N,N-Diisopropyl-P,P-diphenylphosphinamide;Oprea1_621315;DTXSID90395533;N,N-Diisopropyldiphenylphosphinamide;AKOS005448142;N,N-Diisopropyl-P,P-diphenylphosphinic amide;P,P-diphenyl-N,N-dipropan-2-ylphosphinic amide;N,N-Diisopropyl-P,P-diphenylphosphinamide, 97%

Chemical Property of N-diphenylphosphoryl-N-propan-2-ylpropan-2-amine

Chemical Property:

• XLogP3: 4.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 301.159551387
• Heavy Atom Count: 21
• Complexity: 324

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)N(C(C)C)P(=O)(C1=CC=CC=C1)C2=CC=CC=C2

Technology Process of N-diphenylphosphoryl-N-propan-2-ylpropan-2-amine

There total 5 articles about N-diphenylphosphoryl-N-propan-2-ylpropan-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

chloro-diphenylphosphine (1079-66-9,74391-44-9) + diisopropylamine (108-18-9) → N,N-Di-isopropyl-P,P-diphenylphosphinic amide (131173-04-1)

Guidance literature:

chloro-diphenylphosphine; diisopropylamine; In toluene; at 0 - 20 ℃; Inert atmosphere;

With dihydrogen peroxide; In toluene; at 0 ℃; for 1.33333h; Inert atmosphere;

DOI:10.1055/s-0029-1216897

Reference yield: 85.0%

diisopropylamine (108-18-9) + Diphenylphosphinic chloride (1499-21-4) → N,N-Di-isopropyl-P,P-diphenylphosphinic amide (131173-04-1)

Guidance literature:

diisopropylamine; With n-butyllithium; In tetrahydrofuran; at -35 ℃; for 1h;

Diphenylphosphinic chloride; In tetrahydrofuran; at -78 - 20 ℃; for 2h;

DOI:10.1055/s-2007-967976

Reference yield:

chloro-diphenylphosphine (1079-66-9,74391-44-9) + isopropylamine (75-31-0) → N,N-Di-isopropyl-P,P-diphenylphosphinic amide (131173-04-1)

Guidance literature:

chloro-diphenylphosphine; isopropylamine; With triethylamine;

With dihydrogen peroxide;

DOI:10.1021/acscatal.5b01490

upstream raw materials:

diisopropylamine

Diphenylphosphinic chloride

chloro-diphenylphosphine

isopropylamine

Downstream raw materials:

P-{2-[bis(2-methylphenyl)phosphino]phenyl}-N,N-diisopropyl-P-phenylphosphinic amide

P-[2-(diphenylphosphino)phenyl]-N,N-diisopropyl-P-phenylphosphinic amide

P-[2-(dicyclohexylphosphino)phenyl]-N,N-diisopropyl-P-phenylphosphinic amide