Methyl N-Boc-3-(naphthalen-2-yl)-L-alaninate

Base Information

Chemical Name:Methyl N-Boc-3-(naphthalen-2-yl)-L-alaninate
CAS No.:176896-73-4
Molecular Formula:C19H23NO4
Molecular Weight:329.396
Hs Code.:2924299090
DSSTox Substance ID:DTXSID80470661
Nikkaji Number:J2.301.119K
Wikidata:Q82298818
Mol file:176896-73-4.mol

Synonyms:176896-73-4;Methyl N-Boc-3-(naphthalen-2-yl)-L-alaninate;(S)-2-TERT-BUTOXYCARBONYLAMINO-3-NAPHTHALEN-2-YL-PROPIONIC ACID METHYL ESTER;methyl (2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-naphthalen-2-ylpropanoate;SCHEMBL5630007;(S)-Methyl 2-((tert-butoxycarbonyl)amino)-3-(naphthalen-2-yl)propanoate;DTXSID80470661;GUZJZIQXCBCAGJ-INIZCTEOSA-N;methyl (2S)-2-{[(tert-butoxy)carbonyl]amino}-3-(naphthalen-2-yl)propanoate;MFCD11501455;(2S)-2-tert-butoxycarbonylamino-3-(2-naphthyl)propionic acid methyl ester;(S)-2-tert-Butoxycarbonylamino-3-naphthalen-2-yl-propionic acid methyl ester (Boc-2Nal-OMe)

Suppliers and Price of Methyl N-Boc-3-(naphthalen-2-yl)-L-alaninate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
(S)-2-TERT-BUTOXYCARBONYLAMINO-3-NAPHTHALEN-2-YL-PROPIONIC ACID METHYL ESTER 95.00%
1G
$ 420.00

Total 5 raw suppliers

Chemical Property of Methyl N-Boc-3-(naphthalen-2-yl)-L-alaninate

Chemical Property:

PSA：68.12000
LogP:3.65300
XLogP3:4.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:7
Exact Mass:329.16270821
Heavy Atom Count:24
Complexity:443

Purity/Quality:

95% ^*data from raw suppliers

(S)-2-TERT-BUTOXYCARBONYLAMINO-3-NAPHTHALEN-2-YL-PROPIONIC ACID METHYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)NC(CC1=CC2=CC=CC=C2C=C1)C(=O)OC
Isomeric SMILES:CC(C)(C)OC(=O)N[C@@H](CC1=CC2=CC=CC=C2C=C1)C(=O)OC

Technology Process of Methyl N-Boc-3-(naphthalen-2-yl)-L-alaninate

There total 11 articles about Methyl N-Boc-3-(naphthalen-2-yl)-L-alaninate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 67-56-1
methanol

: 56583-58-5,76985-10-9,58438-04-3
N-tert-butoxycarbonyl-3-(2-naphthyl)-L-alanine

: 176896-73-4
methyl (S)-2-[(tert-butoxycarbonyl)amino]-3-(naphthalen-2-yl)propanoate

Guidance literature:: N-tert-butoxycarbonyl-3-(2-naphthyl)-L-alanine; With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; for 0.333333h;

methanol; In tetrahydrofuran; at 20 ℃;

Reference yield: 79.0%

: 580-13-2
2-bromonaphthalene

: 93267-04-0,170848-34-7,889670-02-4
N-(tert-butoxycarbonyl)-L-3-iodoalanine methyl ester

: 176896-73-4
methyl (S)-2-[(tert-butoxycarbonyl)amino]-3-(naphthalen-2-yl)propanoate

Guidance literature:: N-(tert-butoxycarbonyl)-L-3-iodoalanine methyl ester; With iodine; zinc; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;

2-bromonaphthalene; With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In N,N-dimethyl-formamide; at 50 ℃; for 3h; Inert atmosphere;
DOI:10.1021/jo902238n

Reference yield: 74.0%

: 580-13-2
2-bromonaphthalene

: 175844-11-8,402726-50-5
methyl (2R)-2-[(tert-butoxycarbonyl)amino]-3-bromopropionate

: 176896-73-4
methyl (S)-2-[(tert-butoxycarbonyl)amino]-3-(naphthalen-2-yl)propanoate

Guidance literature:: With (1,2-dimethoxyethane)dichloronickel(II); tris-(trimethylsilyl)silane; [4,4′-bis(1,1-dimethylethyl)-2,2′-bipyridine-N1,N1′]bis{3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-κN]phenyl-κC}iridium(III) hexafluorophosphate; sodium carbonate; 4,4'-di-tert-butyl-2,2'-bipyridine; In 1,2-dimethoxyethane; at 30 ℃; for 6h; Sealed tube; Inert atmosphere; Irradiation;
DOI:10.1021/acs.oprd.1c00208