3-Chloro-4'-nitro-1,1'-biphenyl

Base Information

• Chemical Name: 3-Chloro-4'-nitro-1,1'-biphenyl
• CAS No.: 952-22-7
• Molecular Formula: C12H8ClNO2
• Molecular Weight: 233.654
• Hs Code.: 2904909090
• Mol file: 952-22-7.mol

Synonyms:3-Chloro-4'-nitro-1,1'-biphenyl

Chemical Property of 3-Chloro-4'-nitro-1,1'-biphenyl

Chemical Property:

• PSA: 45.82000
• LogP: 4.43840

Purity/Quality:

98% ^*data from raw suppliers

3-Chloro-4'-nitro-1,1'-biphenyl 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Chloro-4'-nitro-1,1'-biphenyl

There total 9 articles about 3-Chloro-4'-nitro-1,1'-biphenyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-chlorophenylboronic acid (63503-60-6) + para-nitrophenyl bromide (586-78-7) → 3‐chloro‐4′‐nitrobiphenyl (952-22-7)

Guidance literature:

With 1,1',1'',1'''-benzene-1,2,4,5-tetrayltetrakis(methylene)tetrakis-(piperidin-4-ol); palladium diacetate; potassium carbonate; In ethanol; water; at 20 ℃;

DOI:10.1002/ejoc.201500353

Reference yield: 85.0%

p-nitrobenzene iodide (636-98-6) + 3-chlorophenylboronic acid (63503-60-6) → 3‐chloro‐4′‐nitrobiphenyl (952-22-7)

Guidance literature:

With potassium carbonate; sulfilimine based palladacycle; In toluene; at 110 ℃; for 2h;

DOI:10.1016/j.tetlet.2004.02.069

Reference yield: 83.0%

3-chlorophenylboronic acid (63503-60-6) + 4-chlorobenzonitrile (100-00-5) → 3‐chloro‐4′‐nitrobiphenyl (952-22-7)

Guidance literature:

With dichloro bis(acetonitrile) palladium(II); C₁₀H₁₁N₃S; potassium tert-butylate; tetrabutylammomium bromide; In N,N-dimethyl-formamide; at 110 ℃;

DOI:10.1016/j.jcat.2019.07.004

upstream raw materials:

5-chloro-4'-nitro-biphenyl-2-ylamine

nitrobenzene

3-chloro-aniline

4-nitro-aniline

Downstream raw materials:

3'-Chlor-4-<4-decyloxy-benzylidenamino>-biphenyl

3'-chloro-[1,1'-biphenyl]-4-carboxylic acid

3'-chloro-[1,1'-biphenyl]-4-amine

3'-Chlor-4-<4-nonyloxy-benzylidenamino>-biphenyl

Refernces

• 1、 Pentsak, Evgeniy O.,Ananikov, Valentine P.. "Pseudo-Solid-State Suzuki–Miyaura Reaction and the Role of Water Formed by Dehydration of Arylboronic Acids". supporting information. p. 4239 - 4247. Retrieved 2019/06/17.
• 2、 Yakukhnov, Sergey A.,Pentsak, Evgeniy O.,Galkin, Konstantin I.,Mironenko, Roman M.,Drozdov, Vladimir A.,Likholobov, Vladimir A.,Ananikov, Valentine P.. "Rapid “Mix-and-Stir” Preparation of Well-Defined Palladium on Carbon Catalysts for Efficient Practical Use". . p. 1869 - 1873. Retrieved 2018/04/30.