(3β,5β)-Tetrahydro 11-Deoxycorticosterone 21-Acetate

Base Information

• Chemical Name: (3β,5β)-Tetrahydro 11-Deoxycorticosterone 21-Acetate
• CAS No.: 10147-45-2
• Molecular Formula: C₂₃H₃₆O₄
• Molecular Weight: 376.536
• Mol file: 10147-45-2.mol

Synonyms:21-Acetoxy-3beta-hydroxy-5beta-pregnan-20-one

Chemical Property of (3β,5β)-Tetrahydro 11-Deoxycorticosterone 21-Acetate

Chemical Property:

• PSA: 63.60000
• LogP: 4.13840
• Solubility.: Dichloromethane, Ethyl Acetate

Purity/Quality:

98%,99%, ^*data from raw suppliers

(3β,5β)-Tetrahydro11-Deoxycorticosterone21-Acetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (3β,5β)-Tetrahydro 11-Deoxycorticosterone 21-Acetate displays efficient blocking activity towards 3α-hydroxypregnane-steroid action but minimal activity against GABA.

Technology Process of (3β,5β)-Tetrahydro 11-Deoxycorticosterone 21-Acetate

There total 14 articles about (3β,5β)-Tetrahydro 11-Deoxycorticosterone 21-Acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

isopregnanolone (516-55-2) → (3β,5α)-21-(acetyloxy)-3-hydroxypregnan-20-one (2402-24-6,10147-45-2,56193-58-9,96611-83-5,26302-59-0)

Guidance literature:

With lead(IV) acetate; trifluoroborane diethyl ether; In methanol; benzene;

Reference yield: 14.0%

21-acetoxypregnenolone (566-78-9) → (3β,5α)-21-(acetyloxy)-3-hydroxypregnan-20-one (2402-24-6,10147-45-2,56193-58-9,96611-83-5,26302-59-0)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol; Inert atmosphere;

DOI:10.1021/jm300317k

Reference yield:

21-bromo-3β-hydroxy-5β-pregnanone-(20) (51296-50-5,95341-20-1) + potassium acetate (127-08-2) → UC1030 (10147-45-2)

Guidance literature:

With acetic acid;

DOI:10.1021/ja01254a004

upstream raw materials:

isopregnanolone

lead(IV) tetraacetate

acetic acid

21-acetoxypregnenolone

Downstream raw materials:

21-acetoxy-3β-(toluene-4-sulfonyloxy)-5α-pregnan-20-one

(3β,5α)-3,21-dihydroxypregnan-20-one

21-acetoxy-5β-pregnane-3,20-dione

3β,21-diacetoxy-5α-pregnan-20-one

Refernces

• 1、 -. "INHIBITORS OF GLUCOSE-6-PHOSPHATE DEHYDROGENASE FOR TREATING CARDIOVASCULAR AND PULMONARY CONDITIONS". Page/Page column 41. . Retrieved 2018/06/06.
• 2、 -. "METHODS, COMPOSITIONS, AND COMPOUNDS FOR ALLOSTERIC MODULATION OF THE GABA RECEPTOR BY MEMBERS OF THE ANDROSTANE AND PREGNANE SERIES". . . Retrieved 2008/06/13.