1H-Pyrrolo[2,3-b]pyridine-3-carboxaldehyde, 6-broMo-

Base Information

• Chemical Name: 1H-Pyrrolo[2,3-b]pyridine-3-carboxaldehyde, 6-broMo-
• CAS No.: 383875-60-3
• Molecular Formula: C₈H₅BrN₂O
• Molecular Weight: 225.044
• Hs Code.: 2933990090
• Mol file: 383875-60-3.mol

Synonyms:1H-Pyrrolo[2,3-b]pyridine-3-carboxaldehyde, 6-broMo-;6-BroMo-7-azaindole-3-carbaldehyde

Chemical Property of 1H-Pyrrolo[2,3-b]pyridine-3-carboxaldehyde, 6-broMo-

Chemical Property:

• PKA: 11.45±0.40(Predicted)
• PSA: 45.75000
• Density: 1.830±0.06 g/cm3(Predicted)
• LogP: 2.13790
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

6-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Pyrrolo[2,3-b]pyridine-3-carboxaldehyde, 6-broMo-

There total 4 articles about 1H-Pyrrolo[2,3-b]pyridine-3-carboxaldehyde, 6-broMo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

acetic acid (64-19-7,77671-22-8) + 6-Bromo-1H-pyrrolo<2,3-b>pyridine (143468-13-7) → 6-bromo-1H-pyrrolo[2,3-b]pyridine-3-carboxaldehyde (383875-60-3)

Guidance literature:

With hexamethylenetetramine; In water; at 120 ℃; Sealed tube;

Reference yield:

1H-Pyrrolo[2,3-b]pyridine-7-oxide (55052-24-9) → 6-bromo-1H-pyrrolo[2,3-b]pyridine-3-carboxaldehyde (383875-60-3)

Guidance literature:

Multi-step reaction with 3 steps

1: lithium hexamethyldisilazane / benzene / 2 h / 20 °C / Inert atmosphere

2: sodium hydroxide; water / methanol / 2 h / 20 °C

3: hexamethylenetetramine / water / 120 °C / Sealed tube

With hexamethylenetetramine; water; sodium hydroxide; lithium hexamethyldisilazane; In methanol; water; benzene;

Reference yield:

1-Benzoyl-6-bromo-1H-pyrrolo<2,3-b>pyridine (143468-12-6) → 6-bromo-1H-pyrrolo[2,3-b]pyridine-3-carboxaldehyde (383875-60-3)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide; water / methanol / 2 h / 20 °C

2: hexamethylenetetramine / water / 120 °C / Sealed tube

With hexamethylenetetramine; water; sodium hydroxide; In methanol; water;

upstream raw materials:

hexamethylenetetramine

acetic anhydride

6-Bromo-1H-pyrrolo<2,3-b>pyridine

1H-Pyrrolo[2,3-b]pyridine-7-oxide

Downstream raw materials:

(S)-2-tert-butoxy-2-(7-(4-chlorophenyl)-2-(1,3-dimethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-5-methylbenzo[d]thiazol-6-yl)acetic acid

Refernces

• 1、 -. "Azaindole derivatives, process for their preparation, and their use as antitumor agents". Example 1. . Retrieved 2010/11/29.