143468-12-6

Basic information

• Product Name: 1-BENZOYL-6-BROMO-7-AZAINDOLE
• Synonyms: 1-BENZOYL-6-BROMO-7-AZAINDOLE;(6-bromo-1H-pyrrolo[2,3-b]pyridin-1-yl)(phenyl)methanone
• CAS NO: 143468-12-6
• Molecular Formula: C₁₄H₉BrN₂O
• Molecular Weight: 301.13806
• Mol File: 143468-12-6.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 363.9±35.0 °C(Predicted)
• Appearance: /
• Density: 1.52±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 0.75±0.30(Predicted)
• CAS DataBase Reference: 1-BENZOYL-6-BROMO-7-AZAINDOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BENZOYL-6-BROMO-7-AZAINDOLE(143468-12-6)
• EPA Substance Registry System: 1-BENZOYL-6-BROMO-7-AZAINDOLE(143468-12-6)

Safety Data

• Hazardous Substances Data: 143468-12-6(Hazardous Substances Data)

Usage

General Description

1-BENZOYL-6-BROMO-7-AZAINDOLE is a chemical compound with the molecular formula C14H9BrN2O, which consists of a benzoyl group attached to a bromo-substituted azaindole ring. 1-BENZOYL-6-BROMO-7-AZAINDOLE is primarily used in organic synthesis as a key intermediate for the production of pharmaceuticals, agrochemicals, and materials. It is also used in the synthesis of various heterocyclic compounds and has potential applications in medicinal chemistry due to its pharmacological properties. 1-BENZOYL-6-BROMO-7-AZAINDOLE is known for its ability to form hydrogen bonds and as an electron acceptor, making it a versatile building block for the synthesis of diverse organic compounds.

Upstream product

• 271-63-6 7-Azaindole 
• 618-32-6 Benzoyl bromide 
• 55052-24-9 1H-Pyrrolo[2,3-b]pyridine-7-oxide 

Downstream Products

• 1342812-72-9 N-(3,4-difluorophenyl)-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridin-6-amine 
• 143468-08-0 1-Benzoyl-6-cyano-1H-pyrrolo<2,3-b>pyridine 
• 1342948-90-6 N-(3,5-difluorophenyl)-1H-pyrrolo[2,3-b]pyridin-6-amine 
• 1342812-74-1 N-(3,5-difluorophenyl)-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridin-6-amine 
• 1342948-87-1 N-(3,4-difluorophenyl)-1H-pyrrolo[2,3-b]pyridin-6-amine 
• 1542067-06-0 6-biphenyl-4-ylpyrrolo[2,3-b]pyridine-1-carboxylic acid amide 
• 1542067-03-7 6-(4-fluorophenyl)pyrrolo[2,3-b]pyridine-1-carboxylic acid amide 
• 1542067-01-5 6-(4-dimethylaminophenyl)pyrrolo[2,3-b]pyridine-1-carboxylic acid amide 
• 1542066-99-8 6-(4-methoxyphenyl)pyrrolo[2,3-b]pyridine-1-carboxylic acid amide 
• 1542066-97-6 6-phenylpyrrolo[2,3-b]pyridine-1-carboxylic acid amide 
• 1542067-37-7 6-(4-phenylphenyl)-1H-pyrrolo[2,3-b]pyridine 
• 1584679-77-5 2-[6-(4-pyrrolidin-1-ylmethylphenyl)pyrrolo[2,3-b]pyridin-1-yl]acetamide 
• 1542067-55-9 6-(4-piperidin-1-ylmethylphenyl)-1H-pyrrolo[2,3-b]pyridine 
• 1542067-50-4 4-[[4-(1H-pyrrolo[2,3-b]pyridin-6-yl)phenyl]methyl]morpholine 

Relevant articles and documents

Discovery and characterization of novel indole and 7-azaindole derivatives as inhibitors of β-amyloid-42 aggregation for the treatment of Alzheimer's disease

The aggregation of amyloid-β peptides into cytotoxic oligomeric and fibrillary aggregates is believed to be one of the major pathological events in Alzheimer disease. Here we report the design and synthesis of a novel series of indole and 7-azaindole derivatives containing, nitrile, piperidine and N-methyl-piperidine substituents at the 3-position to prevent the pathological self-assembly of amyloid-β. We have further demonstrated that substitution of the azaindole and indole derivatives at the 3 positions is required to obtain compounds with improved physicochemical properties to allow brain penetration.

ANTICANCER AGENT

An anticancer agent comprising a compound represented by the formula (I) [R1 represents hydrogen atom, hydroxyl group, a C1-6alkoxy group and the like; R2 and R3 represents hydrogen atom, a halogen atom, a C1-6alkyl group and the like; R4 represents hydrogen atom, a C1-6alkyl group, a C1-6alkylsulfonyl group and the like; R5 represents hydrogen atom or a substituent; .... represents a single bond or a double bond; R6 and R7 represents hydrogen atom, a C1-6alkyl group and the like; R8 represents hydrogen atom, a C1-6alkyl group and the like; A represents -O-, -S-, or - CH2-; D represents -C= or -N=; X represents methylene group, -O-, or -CO-; Q represents -N= or -C(R8)=; and Y represents a heterocyclic group or amino group], which shows a superior inhibitory activity against pim-1 kinase.

Novel Compounds for the Treatment of Diseases Associated with Amyloid or Amyloid-Like Proteins

The present invention relates to novel compounds that can be employed in the treatment of a group of disorders and abnormalities associated with amyloid protein, such as Alzheimer's disease, and of diseases or conditions associated with amyloid-like proteins. The compounds of the present invention can also be used in the treatment of ocular diseases associated with pathological abnormalities/changes in the tissues of the visual system. The present invention further relates to pharmaceutical compositions comprising these compounds and to the use of these compounds for the preparation of medicaments for treating or preventing diseases or conditions associated with amyloid and/or amyloid-like proteins. A method of treating or preventing diseases or conditions associated with amyloid and/or amyloid-like proteins is also disclosed.