143468-13-7

Basic information

• Product Name: 6-BROMO-1H-PYRROLO[2,3-B]PYRIDINE
• Synonyms: 6-BROMO-1H-PYRROLO[2,3-B]PYRIDINE;6-BROMO-7-AZAINDOLE;1H-Pyrrolo[2,3-b]pyridine, 6-bromo-;6-broMo-;6-broMo-1H-pyrrolo[2
• CAS NO: 143468-13-7
• Molecular Formula: C₇H₅BrN₂
• Molecular Weight: 197.03
• EINECS: 1533716-785-6
• Product Categories: Azaindoles
• Mol File: 143468-13-7.mol
• Article Data: 7

Chemical Properties

• Melting Point: 192-195℃
• Boiling Point: 438.7±37.0 °C(Predicted)
• Appearance: Off-white to yellow/Solid
• Density: 1.771 g/cm³
• Refractive Index: 1.728
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 6.76±0.40(Predicted)
• CAS DataBase Reference: 6-BROMO-1H-PYRROLO[2,3-B]PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-BROMO-1H-PYRROLO[2,3-B]PYRIDINE(143468-13-7)
• EPA Substance Registry System: 6-BROMO-1H-PYRROLO[2,3-B]PYRIDINE(143468-13-7)

Safety Data

• Safety Statements: 24/25
• RIDADR: UN2811
• HazardClass: 6.1
• Hazardous Substances Data: 143468-13-7(Hazardous Substances Data)

Usage

General Description

6-Bromo-1H-pyrrolo[2,3-b]pyridine is a chemical compound with the molecular formula C8H6BrN3. It is a heterocyclic compound containing both pyrrole and pyridine rings, and it incorporates a bromine atom at the 6th position of the pyrrole ring. 6-BROMO-1H-PYRROLO[2,3-B]PYRIDINE is commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals. It has shown potential in medicinal chemistry as a core structure for developing new drugs due to its ability to interact with biological targets such as enzymes and receptors. Additionally, this compound has been studied for its potential as a fungicide and herbicide.

InChI:InChI=1/C7H5BrN2/c8-6-2-1-5-3-4-9-7(5)10-6/h1-4H,(H,9,10)

Upstream product

• 271-63-6 7-Azaindole 
• 55052-24-9 1H-Pyrrolo[2,3-b]pyridine-7-oxide 
• 143468-12-6 1-Benzoyl-6-bromo-1H-pyrrolo<2,3-b>pyridine 

Downstream Products

• 1342812-72-9 N-(3,4-difluorophenyl)-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridin-6-amine 
• 383875-60-3 6-bromo-1H-pyrrolo[2,3-b]pyridine-3-carboxaldehyde 
• 145901-11-7 6-amino-1H-pyrrolo<2,3-b>pyridine 
• 7631-86-9 SiO₂ 
• 934568-29-3 6-bromo-1-methyl-1H-pyrrolo[2,3-b]pyridine 
• 189882-33-5 1H-pyrrolo[2,3-b]pyridine-6-carbonitrile 

Relevant articles and documents

Discovery and characterization of novel indole and 7-azaindole derivatives as inhibitors of β-amyloid-42 aggregation for the treatment of Alzheimer's disease

The aggregation of amyloid-β peptides into cytotoxic oligomeric and fibrillary aggregates is believed to be one of the major pathological events in Alzheimer disease. Here we report the design and synthesis of a novel series of indole and 7-azaindole derivatives containing, nitrile, piperidine and N-methyl-piperidine substituents at the 3-position to prevent the pathological self-assembly of amyloid-β. We have further demonstrated that substitution of the azaindole and indole derivatives at the 3 positions is required to obtain compounds with improved physicochemical properties to allow brain penetration.

ANTICANCER AGENT

An anticancer agent comprising a compound represented by the formula (I) [R1 represents hydrogen atom, hydroxyl group, a C1-6alkoxy group and the like; R2 and R3 represents hydrogen atom, a halogen atom, a C1-6alkyl group and the like; R4 represents hydrogen atom, a C1-6alkyl group, a C1-6alkylsulfonyl group and the like; R5 represents hydrogen atom or a substituent; .... represents a single bond or a double bond; R6 and R7 represents hydrogen atom, a C1-6alkyl group and the like; R8 represents hydrogen atom, a C1-6alkyl group and the like; A represents -O-, -S-, or - CH2-; D represents -C= or -N=; X represents methylene group, -O-, or -CO-; Q represents -N= or -C(R8)=; and Y represents a heterocyclic group or amino group], which shows a superior inhibitory activity against pim-1 kinase.

Novel Compounds for the Treatment of Diseases Associated with Amyloid or Amyloid-Like Proteins

The present invention relates to novel compounds that can be employed in the treatment of a group of disorders and abnormalities associated with amyloid protein, such as Alzheimer's disease, and of diseases or conditions associated with amyloid-like proteins. The compounds of the present invention can also be used in the treatment of ocular diseases associated with pathological abnormalities/changes in the tissues of the visual system. The present invention further relates to pharmaceutical compositions comprising these compounds and to the use of these compounds for the preparation of medicaments for treating or preventing diseases or conditions associated with amyloid and/or amyloid-like proteins. A method of treating or preventing diseases or conditions associated with amyloid and/or amyloid-like proteins is also disclosed.