2-CHLORO-4-(4-CHLOROPHENYL)-5-THIAZOLECARBOXYLIC ACID ETHYL ESTER

Base Information

Chemical Name:2-CHLORO-4-(4-CHLOROPHENYL)-5-THIAZOLECARBOXYLIC ACID ETHYL ESTER
CAS No.:74476-54-3
Molecular Formula:C12H9Cl2NO2S
Molecular Weight:0
Hs Code.:
Mol file:74476-54-3.mol

Synonyms:2-CHLORO-4-(4-CHLOROPHENYL)-5-THIAZOLECARBOXYLIC ACID ETHYL ESTER

Suppliers and Price of 2-CHLORO-4-(4-CHLOROPHENYL)-5-THIAZOLECARBOXYLIC ACID ETHYL ESTER

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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price

Total 3 raw suppliers

Chemical Property of 2-CHLORO-4-(4-CHLOROPHENYL)-5-THIAZOLECARBOXYLIC ACID ETHYL ESTER

Chemical Property:

Melting Point:119 - 120 °C (ethanol)
PSA：67.43000
LogP:4.29360

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of 2-CHLORO-4-(4-CHLOROPHENYL)-5-THIAZOLECARBOXYLIC ACID ETHYL ESTER

There total 5 articles about 2-CHLORO-4-(4-CHLOROPHENYL)-5-THIAZOLECARBOXYLIC ACID ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 74476-53-2
ethyl 2-amino-4-(4-chlorophenyl)-1,3-thiazole-5-carboxylate

: 74476-54-3
ethyl 2-chloro-4-(p-chlorophenyl)-5-thiazolecarboxylate

Guidance literature:: With tert.-butylnitrite; copper dichloride; In acetonitrile; 1.) room temperature, 2 h, 2.) 65 deg C, 1 h;;

Reference yield:

: 24045-75-8
ethyl 2-chloro-3-(4-chlorophenyl)-3-oxopropanoate

: 74476-54-3
ethyl 2-chloro-4-(p-chlorophenyl)-5-thiazolecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / ethanol / 16 h / Heating

2: 70 percent / t-butylnitrite, CuCl₂ / acetonitrile / 1.) room temperature, 2 h, 2.) 65 deg C, 1 h;

With tert.-butylnitrite; copper dichloride; In ethanol; acetonitrile;

Reference yield:

: 122-01-0
4-chloro-benzoyl chloride

: 74476-54-3
ethyl 2-chloro-4-(p-chlorophenyl)-5-thiazolecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 38 percent / 1.) aq. NaOH, 2.) aq. NH₃, NH₄Cl; / 1.) benzene, 35 deg C, 3 h, 2.) 40-50 deg C, 3 h;

2: SO₂Cl₂

3: 80 percent / ethanol / 16 h / Heating

4: 70 percent / t-butylnitrite, CuCl₂ / acetonitrile / 1.) room temperature, 2 h, 2.) 65 deg C, 1 h;

With ammonium hydroxide; sodium hydroxide; tert.-butylnitrite; sulfuryl dichloride; ammonium chloride; copper dichloride; In ethanol; acetonitrile;