2-(4-methoxyphenyl)-1-indanone

Base Information

• Chemical Name: 2-(4-methoxyphenyl)-1-indanone
• CAS No.: 1086-43-7
• Molecular Formula: C₁₆H₁₄O₂
• Molecular Weight: 238.286
• Mol file: 1086-43-7.mol

Synonyms:2-(4-methoxyphenyl)-1-indanone

Chemical Property of 2-(4-methoxyphenyl)-1-indanone

Chemical Property:

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-methoxyphenyl)-1-indanone

There total 14 articles about 2-(4-methoxyphenyl)-1-indanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

(E)-1-formyl-2-[2-(4-methoxyphenyl)ethenyl]benzene (1220094-19-8) → 2-(4-methoxyphenyl)-2,3-dihydro-1H-inden-1-one (1086-43-7)

Guidance literature:

With bis(norbornadiene)rhodium(l)tetrafluoroborate; hydrogen; 1,4-di(diphenylphosphino)-butane; In 1,2-dichloro-ethane; at 80 ℃; for 12h; Schlenk technique; Inert atmosphere; Glovebox;

DOI:10.1016/j.tet.2018.11.057

Reference yield:

3-Phenyl-2-<4-methoxy-phenyl>-propionsaeure-chlorid (39104-22-8) → 2-(4-methoxyphenyl)-2,3-dihydro-1H-inden-1-one (1086-43-7)

Guidance literature:

With aluminium trichloride; In dichloromethane; at 0 ℃; for 0.25h; Yield given;

DOI:10.1021/jm950833d

Reference yield:

(±)-2-(4-methoxyphenyl)-3-phenylpropanoic acid (1769-85-3) → 2-(4-methoxyphenyl)-2,3-dihydro-1H-inden-1-one (1086-43-7)

Guidance literature:

With hydrogen fluoride;

DOI:10.1021/jm00325a013 DOI:10.1021/ja01554a043

upstream raw materials:

(±)-2-(4-methoxyphenyl)-3-phenylpropanoic acid

3-Phenyl-2-<4-methoxy-phenyl>-propionsaeure-chlorid

3-phenyl-2-(4-methoxyphenyl)acrylonitrile

2-(4-methoxyphenyl)-3-phenylpropanenitrile

Downstream raw materials:

2-(4-Methoxyphenyl)-3-indenethiol

Bis<2-(4-methoxyphenyl)-3-indenyl> sulfide

2-(4-methoxyphenyl)-1-indanone oxime methyl ether

2-(4-methoxyphenyl)indanamine

Refernces

• 1、 Kingston, Cian,Guiry, Patrick J.. "Enantiodivergent Synthesis of Tertiary α-Aryl 1-Indanones: Evidence Toward Disparate Mechanisms in the Palladium-Catalyzed Decarboxylative Asymmetric Protonation". . p. 3806 - 3819. Retrieved 2017/04/13.
• 2、 Vaccaro, Wayne,Amore, Cindy,Berger, Joel,Burrier, Robert,Clader, John,Davis, Harry,Domalski, Martin,Fevig, Tom,Salisbury, Brian,Sher, Rosy. "Inhibitors of acyl CoA:cholesterol acyltransferase". . p. 1704 - 1719. Retrieved 2007/10/03.