1769-85-3

Upstream product

• 1694-22-0 (E)-2-(4-methoxyphenyl)-3-phenylacrylic acid 
• 104-01-8 4-Methoxyphenylacetic acid 
• 100-44-7 benzyl chloride 
• 30292-50-3 (E)-3-(4-chlorophenyl)-2-(4-methoxyphenyl)prop-2-enoic acid 
• 100-52-7 benzaldehyde 
• 5840-59-5 3-phenyl-2-(4-methoxyphenyl)acrylonitrile 
• 5840-58-4 2-(4-methoxyphenyl)-3-phenylpropanenitrile 
• 104-47-2 p-methoxybenzylnitrile 

Downstream Products

• 1086-43-7 2-(4-methoxyphenyl)-2,3-dihydro-1H-inden-1-one 
• 39104-22-8 3-Phenyl-2-<4-methoxy-phenyl>-propionsaeure-chlorid 
• 102345-54-0 2-<4-Methoxy-phenyl>-3-<4-(2-diaethylamino-aethoxy)-phenyl>-inden 
• 145962-42-1 2-(4-methoxyphenyl)-1-indanone oxime methyl ether 
• 145962-41-0 2-(4-methoxyphenyl)indanamine 

Relevant academic research and scientific papers

GUANIDINE DERIVATIVES AS TRPC MODULATORS

The present invention is directed to guanidine derivatives as inhibitors of transient receptor potential canonical channels (TRPC channels), in particular TRPC3 and/or TRPC6 and/or TRPC7 activity, more particularly TRPC6 activity. Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders mediated by TRPC channels (Formula (I))

Reactions of chlorine substituted (E)-2,3-diphenylpropenoic acids over cinchonidine-modified Pd: Enantioselective hydrogenation versus hydrodechlorination

The effect of the chlorine position on the C-Cl bond hydrogenolysis and the enantioselective hydrogenation of Cl substituted (E)-2,3-diphenylpropenoic acid derivatives has been studied over cinchonidine-modified Pd/Al2O 3. In contrast to the fast hydrodechlorination of the β-phenyl-para-Cl substituted acids the Cl on the α-phenyl ring was barely hydrogenolized. These observations were interpreted by the different arrangements of the two phenyl rings on the surface, with the α- and β-phenyl rings adsorbed tilted and parallel, respectively. The results confirmed the beneficial effect of the α-phenyl-ortho-substituents on the chiral discrimination, thus the 2,3-diphenylpropionic acids substituted by Cl on the α-phenyl ring could be prepared in good yields and optical purities. The conclusions were used for the rational design of an acid, i.e. (E)-2-(2-methoxyphenyl)-3-(3,4-difluorophenyl)propenoic acid, which afforded the best optical purity (ee up to 95% at 295 K) described until now in this heterogeneous system.

Inhibitors of acyl CoA:cholesterol acyltransferase

Conformational restriction of previously disclosed acyclic diphenylethyl)diphenylacetamides led to the discovery of several potent inhibitors of acyl CoA:cholesterol acyltransferase (ACAT). cis-[2-(4- Hydroxyphenyl)-1-indanyl]diphenylacetamide (4a) was the most potent ACAT inhibitor identified (IC50 = 0.04 μM in an in vitro rat hepatic microsomal ACAT assay, ED50 = 0.72 mg/kg/day in cholesterol-fed hamsters).