N-(2-methoxy-5-nitrophenyl)formamide

Base Information

• Chemical Name: N-(2-methoxy-5-nitrophenyl)formamide
• CAS No.: 149686-06-6
• Molecular Formula: C8H8N2O4
• Molecular Weight: 196.163
• Hs Code.: 2924299090
• European Community (EC) Number: 638-776-3
• NSC Number: 99632
• DSSTox Substance ID: DTXSID50295101
• Wikidata: Q82034812
• Mol file: 149686-06-6.mol

Synonyms:N-(2-methoxy-5-nitrophenyl)formamide;149686-06-6;2-Methoxy-5-nitroformanilide;2'-Methoxy-5'-nitroformanilide;NSC99632;2-formamido-4-nitroanisole;NCIOpen2_002011;SCHEMBL5226315;DTXSID50295101;WMFURCICLSTGEJ-UHFFFAOYSA-N;NSC-99632;AKOS006272593;N-(2-methoxyl-5-nitrophenyl) formamide;FT-0671292;10.14272/WMFURCICLSTGEJ-UHFFFAOYSA-N.1;doi:10.14272/WMFURCICLSTGEJ-UHFFFAOYSA-N.1

Chemical Property of N-(2-methoxy-5-nitrophenyl)formamide

Chemical Property:

• PSA: 87.64000
• LogP: 2.34440
• Solubility.: DMSO, Ethanol, Ethyl Acetate, Methanol
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 196.04840674
• Heavy Atom Count: 14
• Complexity: 216

Purity/Quality:

97% ^*data from raw suppliers

2-Methoxy-5-nitroformanilide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=C(C=C1)[N+](=O)[O-])NC=O
• Uses: 2-Methoxy-5-nitroformanilide (cas# 149686-06-6) is a compound useful in organic synthesis.

Technology Process of N-(2-methoxy-5-nitrophenyl)formamide

There total 1 articles about N-(2-methoxy-5-nitrophenyl)formamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.1%

formic acid (64-18-6) + 3-amino-4-methoxynitrobenzene (99-59-2) → N-(2-methoxyl-5-nitrophenyl)formamide (149686-06-6)

Guidance literature:

formic acid; With acetic anhydride; at 0 - 32 ℃; for 1h;

3-amino-4-methoxynitrobenzene; at 32 ℃;

Reference yield: 93.0%

N-(2-methoxyl-5-nitrophenyl)formamide (149686-06-6) → N-(5-amino-2-methoxylphenyl)formamide (78939-34-1)

Guidance literature:

With hydrogen; platinum(IV) oxide; In ethanol; at 65 ℃;

DOI:10.1021/ja00408a067

Reference yield: 88.0%

4-chloro-2-methanesulfonylpyrimidine (97229-11-3) + N-(2-methoxyl-5-nitrophenyl)formamide (149686-06-6) → 4-chloro-N-(2-methoxy-5-nitrophenyl)pyrimidin-2-amine

Guidance literature:

N-(2-methoxyl-5-nitrophenyl)formamide; With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil; at 0 - 25 ℃; for 0.5h;

4-chloro-2-methanesulfonylpyrimidine; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.5h;

upstream raw materials:

formic acid

3-amino-4-methoxynitrobenzene

Downstream raw materials:

5-Nitro-2-methoxy-phenyl-isocyaniddichlorid

N-(5-amino-2-methoxylphenyl)formamide

3-Formylamino-4-methoxy-benzenediazonium; chloride

N-methyl-2-methoxy-5-nitroaniline

Refernces

• 1、 -. "PYRROLOQUINOLINE QUINONE DISODIUM SALT CRYSTAL". Paragraph 0106; 0107; 0108; 0109. . Retrieved 2015/11/10.
• 2、 -. "SYNTHESIS OF PYRROLOQUINOLINE QUINONE (PQQ)". Page/Page column 8; 13; 1/6. . Retrieved 2010/11/24.