Methyl 4-amino-3-bromo-5-fluorobenzoate

Base Information

• Chemical Name: Methyl 4-amino-3-bromo-5-fluorobenzoate
• CAS No.: 1123171-91-4
• Molecular Formula: C8H7BrFNO2
• Molecular Weight: 248.051
• Hs Code.: 2922499990
• Mol file: 1123171-91-4.mol

Synonyms:Methyl 4-amino-3-bromo-5-fluorobenzoate;2-Bromo-6-fluoro-4-(methoxycarbonyl)aniline;Methyl 4-amino-3-bromo-5-fluorobenzoate 95+%

Chemical Property of Methyl 4-amino-3-bromo-5-fluorobenzoate

Chemical Property:

• Boiling Point: 327.0±42.0 °C(Predicted)
• PKA: -0.99±0.10(Predicted)
• PSA: 52.32000
• Density: 1.653±0.06 g/cm3(Predicted)
• LogP: 2.53820
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

97% ^*data from raw suppliers

Methyl4-Amino-3-bromo-5-fluorobenzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 4-amino-3-bromo-5-fluorobenzoate

There total 1 articles about Methyl 4-amino-3-bromo-5-fluorobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 4-amino-3-fluorobenzene carboxylate (185629-32-7) → methyl 4-amino-3-bromo-5-fluorobenzoate (1123171-91-4)

Guidance literature:

With Oxone; sodium bromide; In water; acetonitrile; at 25 ℃; for 2h;

Reference yield: 83.0%

methyl 4-amino-3-bromo-5-fluorobenzoate (1123171-91-4) + cyclopropylboronic acid (411235-57-9) → methyl 4-amino-3-cyclopropyl-5-fluorobenzoate

Guidance literature:

With potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; at 100 ℃; for 3h; Inert atmosphere;

Reference yield:

methyl 4-amino-3-bromo-5-fluorobenzoate (1123171-91-4) → methyl-3-bromo-5-fluoro-4-nitrobenzoate (1123171-93-6)

Guidance literature:

With dihydrogen peroxide; trifluoroacetic anhydride; In dichloromethane; water; at 25 - 45 ℃; for 1h;

upstream raw materials:

methyl 4-amino-3-fluorobenzene carboxylate

Downstream raw materials:

4-amino-3-fluoro-5-vinyl-benzoic acid methyl ester

methyl-3-bromo-5-fluoro-4-nitrobenzoate