185629-32-7

Usage

Chemical Properties

Brown solid

InChI:InChI=1/C8H8FNO2/c1-12-8(11)5-2-3-7(10)6(9)4-5/h2-4H,10H2,1H3

Upstream product

• 185629-31-6 methyl 3-fluoro-4-nitrobenzoate 
• 5081-36-7 3-methoxy-4-nitrobenzoic acid 
• 403-21-4 3-fluoro-4-nitrobenzoic acid 
• 369-25-5 methyl 3,4-difluorobenzoate 
• 67-56-1 methanol 
• 455-87-8 4-amino-3-fluorobenzoic acid 

Downstream Products

• 301674-58-8 methyl 3-fluoro-4-(N-sulfinyl)aminobenzoate 
• 924287-64-9 methyl 2-amino-4-fluoro-1,3-benzothiazole-6-carboxylate 
• 1123171-91-4 methyl 4-amino-3-bromo-5-fluorobenzoate 
• 1123172-01-9 4-amino-3-fluoro-5-iodobenzoic acid methyl ester 
• 1449410-47-2 methyl 4-{[4-chloro-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-yl]amino}-3-fluorobenzoate 
• 1449398-09-7 N₁-(3-(4-{[4-{[1-(4-chlorophenyl)cyclopropyl]amino}-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-yl]amino}-3-fluorobenzamido)-2,2-dimethylpropyl)-N₂,N₂-dimethyloxalamide 
• 1449398-08-6 4-{[4-{[1-(4-chlorophenyl)cyclopropyl]amino}-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-yl]amino}-N-{2,2-dimethyl-3-[2-oxo-2-(pyrrolidin-1-yl)acetamido]propyl}-3-fluorobenzamide 
• 1449410-51-8 N-(3-amino-2,2-dimethylpropyl)-4-{[4-{[1-(4-chlorophenyl)cyclopropyl]amino}-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-yl]amino}-3-fluorobenzamide 
• 1449410-50-7 tert-butyl 3-(4-{[4-{[1-(4-chlorophenyl)cyclopropyl]amino}-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-yl]amino}-3-fluorobenzamido)-2,2-dimethylpropylcarbamate 
• 1449410-49-4 4-{[4-{[1-(4-chlorophenyl)cyclopropyl]amino}-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-yl]amino}-3-fluorobenzoic acid 
• 1449410-48-3 methyl 4-{[4-{[1-(4-chlorophenyl)cyclopropyl]amino}-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-yl]amino}-3-fluorobenzoate 
• 1383816-38-3 C₂₉H₂₆F₄N₄O₄S 
• 1383816-29-2 2-[(1R,3r,5S)-3-({5-cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-1,2-oxazol-4-yl}methoxy)-8-azabicyclo[3.2.1]octan-8-yl]-4-fluoro-1,3-benzothiazole-6-carboxylic acid 
• 1383816-28-1 methyl-2-(3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)-4-fluorobenzo[d]thiazole-6-carboxylate 

Relevant academic research and scientific papers

Exploring boron applications in modern agriculture: A structure-activity relationship study of a novel series of multi-substitution benzoxaboroles for identification of potential fungicides

Several boron-containing small molecules have been approved by the US FDA to treat human diseases. We explored potential applications of boron-containing compounds in modern agriculture by pursuing multiple research and development programs. Here, we report a novel series of multi-substitution benzoxaboroles (1–36), a compound class that we recently reported as targeting geranylgeranyl transferase I (GGTase I) and thereby inhibiting protein prenylation (Kim et al., 2020). These compounds were designed, synthesized, and tested against the agriculturally important fungal pathogens Mycosphaerella fijiensis and Colletotrichum sublineolum in a structure–activity relationship (SAR) study. Compounds 13, 28, 30, 34 and 36 were identified as active leads with excellent antifungal MIC95 values in the range of 1.56–3.13 ppm against M. fijiensis and 0.78–3.13 ppm against C. sublineolum.

FXR RECEPTOR AGONIST

The present invention belongs to the technical field of pharmaceuticals, and particularly relates to a compound of formula (I), a pharmaceutically acceptable salt thereof, an ester thereof or a stereoisomer of the compound, the salt or the ester, wherein

NEW CLASS OF DNA GYRASE AND/OR TOPOISOMERASE IV INHIBITORS WITH ACTIVITY AGAINST GRAM-POSITIVE AND GRAM-NEGATIVE BACTERIA

The present invention relates to compounds having a structure of general formula (I), processes for their preparation, pharmaceutical compositions containing them as the active ingredient, to their use as medicaments and to their use in the manufacture of medicaments for use in the treatment of bacterial infections in humans and warm-blooded animals.

BORON CONTAINING COMPOUNDS AND THEIR USES

The present disclosure contemplates novel boron-containing compounds and their uses as active agents that exhibit pesticidal activity such as antimicrobial, insecticidal, arachnicidal, and/or anti parasitic activity. An agrochemical composition containing such a compound and its use in, animal health, agriculture, or horticulture is also contemplated. A method for promoting plant performance and/or controlling, reducing, preventing, ameliorating, or inhibiting microbes, insects, arachnids, and/or parasites on or in an animal, a plant, a plant part, plant propagation material, and/or harvested fruits or vegetables is also contemplated.

FXR receptor agonist

The present invention discloses an FXR receptor agonist, belongs to the technical field of medicine, and particularly relates to a compound represented by a formula (I), a pharmaceutically acceptablesalt, an ester or a stereoisomer thereof, wherein R, R, R, M, L, L1, W, A , B, Q, m and n are defined in the specification. The present invention further relates to a preparation method of the compound, a pharmaceutical preparation, and applications in preparation of drugs for treatment and/or prevention of nonalcoholic fatty liver disease, primary biliary cirrhosis, lipid metabolism disorder, diabetic complication, malignant tumors and other related diseases mediated by FXR receptors. The formula I is defined in the specification.

Anion ligand promoted selective C-F bond reductive elimination enables C(sp2)-H fluorination

A detailed mechanism study on the anion ligand promoted selective C-H bond fluorination is reported. The role of the anion ligand has been clarified by experimental evidence and DFT calculations. Moreover, the nitrate promoted C-F bond reductive elimination enabled a selective C-H bond fluorination of various symmetric and asymmetric azobenzenes to access diverse o-fluoroanilines.

COMPOUNDS AND METHOD OF USE

This present disclosure relates to compounds with ferroptosis inducing activity, a method of treating a subject with cancer with the compounds, and combination treatments with a second therapeutic agent.

FXR RECEPTOR MODULATOR, PREPARATION METHOD THEREFOR, AND USES THEREOF

The present disclosure disclosed a modulator of FXR receptor and preparation and use thereof, which relates to the technical filed of medicinal chemistry. The present disclosure provides a modulator of FXR receptor having a structural formula I or a pharmaceutically acceptable salt, stereoisomer, solvate or prodrug thereof, which can combine with FXR receptor (that is NR1H4) and be acted as a FXR agonist or a partial agonist for preventing and treating the disease mediated by FXR, such as chronic intrahepatic or extrahepatic cholestasis, hepatic fibrosis caused by chronic cholestasis or acute intrahepatic cholestasis, chronic hepatitis B, gallstone, hepatic carcinoma, colon cancer or intestinal inflammatory disease, etc. Specifically, for some chemical compounds, their EC50 for FXR agonist activity reach below 100nM, which show an excellent FXR agonist activity and an excellent prospect to provide a new pharmaceutical selection in clinical treatment for the disease mediated by FXR.

Silver-catalyzed intermolecular amination of fluoroarenes

A novel highly selective Ag-catalyzed intermolecular amination of fluoroarenes has been developed. This transformation starts from readily available 4-carbonyl fluorobenzene and NaN3 or other nitrogen-source, via amination followed by C-F bond cleavage, thus affording the desired 4-carbonyl arylamine products under mild conditions. The reaction is accelerated using a small amount of water. This pathway is distinct from a previously reported radical amination reaction.