Technology Process of 4-(methoxycarbonyl)-4-methylcyclohexanecarboxylic acid
There total 3 articles about 4-(methoxycarbonyl)-4-methylcyclohexanecarboxylic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
lithium hydroxide monohydrate; water;
In
tetrahydrofuran; methanol;
at 20 ℃;
for 2.5h;
- Guidance literature:
-
4-(methoxycarbonyl)cyclohexanecarboxylic acid;
With
lithium diisopropyl amide;
In
tetrahydrofuran; n-heptane; ethylbenzene;
at -78 ℃;
for 0.916667h;
methyl iodide;
In
tetrahydrofuran; n-heptane; ethylbenzene;
at -78 - 20 ℃;
for 4.75833h;
With
hydrogenchloride;
In
tetrahydrofuran; n-heptane; ethylbenzene; water;
at 0 ℃;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: lithium diisopropyl amide / tetrahydrofuran / 0.83 h / -65 °C / Inert atmosphere
1.2: 10 h / -65 - 20 °C / Inert atmosphere
2.1: lithium hydroxide monohydrate; water / tetrahydrofuran; methanol / 2.5 h / 20 °C
With
lithium hydroxide monohydrate; water; lithium diisopropyl amide;
In
tetrahydrofuran; methanol;
