8-benzylidene-1,4-dioxaspiro[4.5]decane

Base Information

• Chemical Name: 8-benzylidene-1,4-dioxaspiro[4.5]decane
• CAS No.: 83631-87-2
• Molecular Formula: C15H18O2
• Molecular Weight: 230.307
• Mol file: 83631-87-2.mol

Synonyms:8-benzylidene-1,4-dioxaspiro[4.5]decane;8-(phenylmethylene)-1,4-Dioxaspiro[4.5]decane

Chemical Property of 8-benzylidene-1,4-dioxaspiro[4.5]decane

Chemical Property:

• PSA: 18.46000
• LogP: 3.38710

Purity/Quality:

98%+ ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 8-benzylidene-1,4-dioxaspiro[4.5]decane

There total 10 articles about 8-benzylidene-1,4-dioxaspiro[4.5]decane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

cyclohexanedione monoethylene ketal (4746-97-8) + benzyl 3,5-bis(trifluoromethyl)phenyl sulfone (667458-78-8) → 8-Benzylidene-1,4-dioxa-spiro[4.5)decane (83631-87-2)

Guidance literature:

With phosphazene base-P₄-tert-butyl; In tetrahydrofuran; hexane; at 0 - 20 ℃;

DOI:10.1002/ejoc.200600478

Reference yield: 74.0%

cyclohexanedione monoethylene ketal (4746-97-8) + benzyltriphenylphosphonium bromide (1449-46-3) → 8-Benzylidene-1,4-dioxa-spiro[4.5)decane (83631-87-2)

Guidance literature:

With sodium hydride; In dimethyl sulfoxide;

DOI:10.1016/j.bmcl.2008.01.053

Reference yield:

cyclohexanedione monoethylene ketal (4746-97-8) + NaH oil + O,O-diethyl benzylphosphonate (1080-32-6) → 8-Benzylidene-1,4-dioxa-spiro[4.5)decane (83631-87-2)

Guidance literature:

In 1,3-dimethyl-2-imidazolidinone; hexane; water; ethyl acetate;

upstream raw materials:

phenylmagnesium bromide

8-[Chloro-(toluene-4-sulfinyl)-methylene]-1,4-dioxa-spiro[4.5]decane

cyclohexanedione monoethylene ketal

benzyl 3,5-bis(trifluoromethyl)phenyl sulfone

Downstream raw materials:

8-benzyl-1,4-dioxaspiro[4.5]decane

4-benzylidenecyclohexanone

4-benzylcyclohexanol

4-benzylidenecyclohexanol