Pyridine, 2-(4,5-dimethyl-1H-imidazol-2-yl)-

Base Information

• Chemical Name: Pyridine, 2-(4,5-dimethyl-1H-imidazol-2-yl)-
• CAS No.: 942223-96-3
• Molecular Formula: C₁₀H₁₁N₃
• Molecular Weight: 173.217
• Mol file: 942223-96-3.mol

Synonyms:Pyridine, 2-(4,5-dimethyl-1H-imidazol-2-yl)-

Chemical Property of Pyridine, 2-(4,5-dimethyl-1H-imidazol-2-yl)-

Chemical Property:

• PSA: 41.57000
• LogP: 2.08850

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pyridine, 2-(4,5-dimethyl-1H-imidazol-2-yl)-

There total 2 articles about Pyridine, 2-(4,5-dimethyl-1H-imidazol-2-yl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

N-methyl-acetamide (79-16-3) + pyridine-2-carboxylic acid amide (1452-77-3) → 2-(4,5-dimethyl-1H-imidazol-2-yl)pyridine (942223-96-3)

Guidance literature:

N-methyl-acetamide; With oxalyl dichloride; In dichloromethane; at 0 ℃; for 0.5h;

pyridine-2-carboxylic acid amide; In dichloromethane; at 20 ℃; for 3h;

DOI:10.1016/j.ica.2016.05.020

Reference yield: 68.0%

pyridine-2-carbaldehyde (1121-60-4) + dimethylglyoxal (431-03-8) → 2-(4,5-dimethyl-1H-imidazol-2-yl)pyridine (942223-96-3)

Guidance literature:

With ammonium acetate; In ethanol; for 24h; Reflux;

DOI:10.1134/S1070363212110230

Reference yield: 62.0%

ammonium hexafluorophosphate + chloro(cyclopentadienyl)bis(triphenylphosphine)ruthenium (II) (32993-05-8) + 2-(4,5-dimethyl-1H-imidazol-2-yl)pyridine (942223-96-3) → [(η5-cyclopentadienyl)Ru(II)(2-(2'-pyridyl)-4,5-dimethylimidazole)(triphenylphosphine)](hexafluorophosphate) (952342-24-4)

Guidance literature:

In methanol; byproducts: NH4Cl; a mixture of Ru-complex, organic ligand and NH4PF6 refluxed in dry methanol under a nitrogen atmosphere for 6 h; solvent evaporated at reduced pressure; residue dissolved in CH2Cl2, andsoln. filtered to remove NH4Cl; soln. concentrated; product precipitate s by adding excess hexane; filtered and dried under vacuum; elem. anal.;

DOI:10.1016/j.poly.2007.03.055

upstream raw materials:

pyridine-2-carbaldehyde

dimethylglyoxal

N-methyl-acetamide

pyridine-2-carboxylic acid amide

Downstream raw materials:

[(η5-cyclopentadienyl)Ru(II)(2-(2'-pyridyl)-4,5-dimethylimidazole)(triphenylphosphine)](hexafluorophosphate)