2-Phenyl-7-hydroxyquinoline

Base Information

• Chemical Name: 2-Phenyl-7-hydroxyquinoline
• CAS No.: 87741-95-5
• Molecular Formula: C15H11NO
• Molecular Weight: 221.25394
• Mol file: 87741-95-5.mol

Synonyms:2-Phenyl-7-hydroxyquinoline;2-Phenylquinolin-7-ol;2-phenyl-7-Quinolinol

Chemical Property of 2-Phenyl-7-hydroxyquinoline

Chemical Property:

• PSA: 32.86000
• LogP: 3.19510

Purity/Quality:

99% ^*data from raw suppliers

2-phenylquinolin-7-ol 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Phenyl-7-hydroxyquinoline

There total 10 articles about 2-Phenyl-7-hydroxyquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

7-methoxy-2-phenylquinoline (21255-17-4) → 7-hydroxy-2-phenylquinoline (87741-95-5)

Guidance literature:

With water; hydrogen bromide; acetic acid;

DOI:10.1021/ja01211a042

Reference yield:

N-benzylidene-m-anisidine (5877-59-8,287930-02-3) → 7-hydroxy-2-phenylquinoline (87741-95-5)

Guidance literature:

Multi-step reaction with 7 steps

1: phosphorus (V)-chloride

2: toluene / Erhitzen des Reaktionsprodukts auf 150-170grad

3: aqueous NaOH

4: 360 °C / Im Vakuum

5: phosphoryl chloride

6: palladium/calcium carbonate; ethanol / Hydrogenation

7: water; hydrobromic acid; acetic acid

With sodium hydroxide; palladium on activated charcoal; Lindlar's catalyst; ethanol; phosphorus pentachloride; water; hydrogen bromide; acetic acid; toluene; trichlorophosphate;

DOI:10.1021/ja01211a042

Reference yield:

7-methoxy-2-phenylquinolin-4-ol (20430-72-2,189816-04-4) → 7-hydroxy-2-phenylquinoline (87741-95-5)

Guidance literature:

Multi-step reaction with 3 steps

1: phosphoryl chloride

2: palladium/calcium carbonate; ethanol / Hydrogenation

3: water; hydrobromic acid; acetic acid

With palladium on activated charcoal; Lindlar's catalyst; ethanol; water; hydrogen bromide; acetic acid; trichlorophosphate;

DOI:10.1021/ja01211a042

upstream raw materials:

7-methoxy-2-phenylquinoline

7-hydroxy-2-phenylquinoline-4-carboxylic acid

N-benzylidene-m-anisidine

7-methoxy-2-phenylquinolin-4-ol

Downstream raw materials:

7-methoxy-2-phenylquinoline

7-amino-2-phenylquinoline

2,8-diphenyl-[1,7]phenanthroline-10-carboxylic acid