2-Phenyl-7-Methoxyquinoline

Base Information

• Chemical Name: 2-Phenyl-7-Methoxyquinoline
• CAS No.: 21255-17-4
• Molecular Formula: C16H13NO
• Molecular Weight: 235.285
• Hs Code.: 2933499090
• Mol file: 21255-17-4.mol

Synonyms:2-Phenyl-7-methoxyquinoline;2-Phenyl-7-methoxy-chinolin;7-Methoxy-2-phenyl-chinolin;7-methoxy-2-phenyl-quinoline;

Chemical Property of 2-Phenyl-7-Methoxyquinoline

Chemical Property:

• PSA: 22.12000
• LogP: 3.91040
• Storage Temp.: 2-8°C

Purity/Quality:

98.5% ^*data from raw suppliers

7-Methoxy-2-phenylquinoline 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Phenyl-7-Methoxyquinoline

There total 15 articles about 2-Phenyl-7-Methoxyquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

7-methoxy-2-(methylthio)quinoline (682350-96-5) → 7-methoxy-2-phenylquinoline (21255-17-4)

Guidance literature:

bis(triphenylphosphine)nickel(II) chloride; In diethyl ether; benzene; at 80 ℃; for 12h;

DOI:10.1055/s-2004-815400

Reference yield: 37.0%

2-aminomethyl-5-methoxy-phenylamine (101251-27-8) + acetophenone (98-86-2) → 7-methoxy-2-phenylquinoline (21255-17-4)

Guidance literature:

With copper(II) bis(trifluoromethanesulfonate); toluene-4-sulfonic acid; In toluene; at 100 ℃; for 36h; Schlenk technique; Sealed tube;

DOI:10.1039/c5ob00075k

Reference yield:

C16H17NO → 7-methoxy-2-phenylquinoline (21255-17-4)

Guidance literature:

With N-iodo-succinimide; In 1,2-dichloro-ethane; at 10 - 20 ℃; for 3h; Irradiation;

DOI:10.1055/s-0039-1691642

upstream raw materials:

diazomethane

7-hydroxy-2-phenylquinoline

4-chloro-7-methoxy-2-phenylquinoline

7-methoxy-2-phenylquinoline-4-carboxylic acid

Downstream raw materials:

7-hydroxy-2-phenylquinoline

C₃₄H₄₁N₃O₇

Refernces

• 1、 Collin et al.. "-". . p. 3069. Retrieved 1968.
• 2、 Xi, Long-Yi,Zhang, Ruo-Yi,Zhang, Lei,Chen, Shan-Yong,Yu, Xiao-Qi. "An efficient synthesis of quinolines via copper-catalyzed C-N cleavage". . p. 3924 - 3930. Retrieved 2015/03/30.