21255-17-4

Usage

Uses

Used in Pharmaceutical Industry:
2-Phenyl-7-Methoxyquinoline is used as a pharmaceutical candidate for its potential applications in the treatment of cancer and other diseases. Its medicinal properties make it a valuable compound for drug development and research in the field of medicinal chemistry.
Used in Materials Science and Organic Electronics:
2-Phenyl-7-Methoxyquinoline is used as a fluorescent material in materials science and organic electronics due to its unique fluorescent properties. This characteristic allows it to be explored for potential applications in various fields, such as sensors, imaging, and optoelectronic devices.

Upstream product

• 186581-53-3 diazomethane 
• 87741-95-5 7-hydroxy-2-phenylquinoline 
• 189816-05-5 4-chloro-7-methoxy-2-phenylquinoline 
• 174636-63-6 7-methoxy-2-phenylquinoline-4-carboxylic acid 
• 5877-59-8 N-benzylidene-m-anisidine 
• 20430-72-2 7-methoxy-2-phenylquinolin-4-ol 
• 1226-34-2 7-hydroxy-2-phenylquinoline-4-carboxylic acid 
• 80819-63-2 N-(3-methoxy-phenyl)-benzimidoyl chloride 
• 101251-27-8 2-aminomethyl-5-methoxy-phenylamine 
• 98-86-2 acetophenone 
• 14425-64-0 4-methoxyphenethyl bromide 
• 100-47-0 benzonitrile 
• 536-90-3 m-Anisidine 
• 873383-40-5 4-hydroxy-7-methoxy-2-phenyl-quinoline-3-carboxylic acid 

Downstream Products

• 87741-95-5 7-hydroxy-2-phenylquinoline 
• 877069-28-8 C₃₄H₄₁N₃O₇ 

Relevant academic research and scientific papers

Heteroannulation of 3-Bis(methylthio)acrolein with Aromatic Amines - A Convenient Highly Regioselective Synthesis of 2-(Methylthio)quinolines and their Benzo/Hetero Fused Analogs: A Modified Skraup Quinoline Synthesis

A simple and efficient synthesis of 2-(methylthio)quinolines and their condensed analogs has been developed through acid-induced cyclocondensation of their respective anilines or aromatic diamines with 3-bis(methylthio)acrolein. The 2-(methylthio) functionality in these quinolines could be either dethiomethylated or replaced by various nitrogen and carbon nucleophiles to afford 2-substituted quinolines.

Preparation of 2-Arylquinolines from 2-Arylethyl Bromides and Aromatic Nitriles with Magnesium and N -Iodosuccinimide

Treatment of 2-arylethylmagnesium bromides, prepared from 2-arylethyl bromides and magnesium, with aromatic nitriles, followed by reaction with water and then with N -iodosuccinimide under irradiation with a tungsten lamp, gave the corresponding 2-arylquinolines in good to moderate yields under transition-metal-free conditions. 2-Alkylquinolines could be also obtained in moderate yields by the same procedure with 2-arylethyl bromides, magnesium, aliphatic nitriles bearing a secondary alkyl group, and N -iodosuccinimide.

An efficient synthesis of quinolines via copper-catalyzed C-N cleavage

An efficient method to synthesize substituted quinolines from ketones and 2-amino benzylamines is described. Copper-catalyzed C-N cleavage of amines followed by condensation with ketones deliver quinolines in moderate to high yields. The broad scope of su