TH287

Base Information

Chemical Name:TH287
CAS No.:1609960-30-6
Molecular Formula:C11H10Cl2N4
Molecular Weight:269.133
Hs Code.:
Mol file:1609960-30-6.mol

Synonyms:TH287;6-(2,3-dichlorophenyl)-N4-methylpyrimidine-2,4-diamine;6-(2,3-Dichlorophenyl)-N4-methylpyrimidine-2,4-diamine hydrochloride;TH287 hydrochloride;6-(2,3-Dichlorophenyl)-N4-methyl-2,4-pyrimidinediamine

Suppliers and Price of TH287

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
6-(2,3-Dichlorophenyl)-N4-methyl-2,4-pyrimidinediamine
1mg
$ 50.00

Sigma-Aldrich
TH287 hydrochloride ≥98% (HPLC)
5mg
$ 124.00

Sigma-Aldrich
TH287 hydrochloride ≥98% (HPLC)
25mg
$ 497.00

DC Chemicals
TH287 >98%
1 g
$ 1500.00

DC Chemicals
TH287 >98%
250 mg
$ 750.00

Crysdot
TH287 98+%
100mg
$ 666.00

Crysdot
TH287 98+%
50mg
$ 415.00

ChemScene
TH287 98.14%
100mg
$ 800.00

ChemScene
TH287 98.14%
10mg
$ 120.00

ChemScene
TH287 98.14%
5mg
$ 75.00

Total 22 raw suppliers

Chemical Property of TH287

Chemical Property:

Boiling Point:512.2±60.0 °C(Predicted)
PKA:5.91±0.10(Predicted)
PSA：37.81000
Density:1.440±0.06 g/cm3(Predicted)
LogP:3.87350
Storage Temp.:2-8°C
Solubility.:DMSO: soluble5mg/mL, clear (warmed)

Purity/Quality:

99%, ^*data from raw suppliers

6-(2,3-Dichlorophenyl)-N4-methyl-2,4-pyrimidinediamine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xn
Statements: 22-41
Safety Statements: 26-39

MSDS Files:: SDS file from LookChem

Useful:

Description Human mutT homolog (MTH1) is a nucleotide pool sanitizing enzyme that cleaves oxidized nucleotides (dNTPs) to prevent incorporation of damaged bases during DNA replication. Cancer cells rely on MTH1 activity in order to avoid cell death. TH287 is an MTH1 inhibitor (IC50 = 0.8 nM) that selectively kills cancer cell lines (IC50s = 0.8-3.06 μM) without significant cytotoxicity towards primary or immortalized cells (IC50s = ≥20 μM). At up to 100 μM it does not show significant effect towards the related nudix hydrolase protein family members MTH2, NUDT5, NUDT12, NUDT14, and NUDT16, as well as other proteins with known nucleoside triphosphate pyrophosphatase activity (dCTPase, dUTPase, and ITPA).
Uses 6-(2,3-Dichlorophenyl)-N4-methyl-2,4-pyrimidinediamine is known to possess antitumor effects and nanomolar MTH1-inhibitory activity in vitro for cancer cell survival.

Technology Process of TH287

There total 3 articles about TH287 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1604677-77-1
4-chloro-6-(2,3-dichlorophenyl)pyrimidin-2-amine

: 74-89-5
methylamine

: 1609960-30-6
6-(2,3-dichlorophenyl)-4-N-methylpyrimidine-2,4-diamine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In butan-1-ol; at 95 ℃;

Reference yield:

: 1005-37-4
2-amino-4-methylamino-6-chloropyrimidine

: 151169-74-3
2,3-dichlorobenzeneboronic acid

: 1609960-30-6
6-(2,3-dichlorophenyl)-4-N-methylpyrimidine-2,4-diamine

Guidance literature:: 2-amino-4-methylamino-6-chloropyrimidine; 2,3-dichlorobenzeneboronic acid; With sodium carbonate; In 1,2-dimethoxyethane; water; for 0.5h; Inert atmosphere;

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; at 90 ℃; for 48h; Inert atmosphere;

Reference yield:

: 151169-74-3
2,3-dichlorobenzeneboronic acid

: 1609960-30-6
6-(2,3-dichlorophenyl)-4-N-methylpyrimidine-2,4-diamine

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; 1,4-dioxane / 2 h / 95 °C / Sealed tube

2: N-ethyl-N,N-diisopropylamine / butan-1-ol / 95 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; water; butan-1-ol;