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Enasidenib

Base Information Edit
Enasidenib

Synonyms:Enasidenib;AG-221;Enasidenib(AG-221);AG-221 (Enasidenib);AG-211;2-Methyl-1-(4-(6-(trifluoromethyl)pyridin-2-yl)-6-(2-(trifluoromethyl)pyridin-4-ylamino)-1,3,5-triazin-2-ylamino)propan-2-ol;2-Propanol, 2-methyl-1-[[4-[6-(trifluoromethyl)-2-pyridinyl]-6-[[2-(trifluoromethyl)-4-pyridinyl]amino]-1,3,5-triazin-2-yl]amino]-;Enasidenib Mesylate

Suppliers and Price of Enasidenib
Supply Marketing:Edit
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • Usbiological
  • AG 221
  • 100mg
  • $ 1296.00
  • TRC
  • Enasidenib
  • 5mg
  • $ 95.00
  • TRC
  • Enasidenib
  • 10mg
  • $ 135.00
  • DC Chemicals
  • AG-221(Enasidenib) >98%
  • 1 g
  • $ 1400.00
  • Crysdot
  • Enasidenib 98+%
  • 50mg
  • $ 502.00
  • Crysdot
  • Enasidenib 98+%
  • 100mg
  • $ 749.00
  • Crysdot
  • Enasidenib 98+%
  • 25mg
  • $ 264.00
  • ChemScene
  • Enasidenib 99.93%
  • 10mg
  • $ 120.00
  • ChemScene
  • Enasidenib 99.93%
  • 5mg
  • $ 84.00
  • ChemScene
  • Enasidenib 99.93%
  • 50mg
  • $ 348.00
Total 42 raw suppliers
Chemical Property of Enasidenib Edit
Chemical Property:
  • Boiling Point:581.0±60.0 °C(Predicted) 
  • PKA:14.70±0.29(Predicted) 
  • PSA:108.74000 
  • Density:1.477±0.06 g/cm3(Predicted) 
  • LogP:4.43860 
  • Storage Temp.:-20°C 
  • Solubility.:Soluble in DMSO (up to 25 mg/ml) 
Purity/Quality:

99% *data from raw suppliers

AG 221 *data from reagent suppliers

Safty Information:
  • Pictogram(s):  
  • Hazard Codes: 
MSDS Files:

SDS file from LookChem

Useful:
  • Description Enasidenib (1446502-11-9) is a potent (IC50’s = 100 nM IDH2R140Q homodimer, 30 nM IDH2R140Q/WT heterodimer and 10 nM IDH2R172K/WT heterodimer) and selective inhibitor of mutant isocitrate dehydrogenase 2 (IDH2).1? It suppressed the production of the oncometabolite (R)-2-Hydroxyglutarate (a competitive inhibitor of αKG-dependent dioxygenases which leads to epigenetic dysregulation) and induced cellular differentiation in primary human IDH2 mutation-positive acute myeloid leukemia cells.1,2? Recently approved for clinical use by the FDA.
  • Uses Enasidenib is a first-in-class oral selective inhibitor of mutant IDH2 enzymes (isocitrate dehydrogenase 2), for the treatment of adults with relapsed or refractory IDH2-mutated acute myeloid leukemia.
Technology Process of Enasidenib

There total 12 articles about Enasidenib which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
4-chloro-6-(6-(trifluoromethyl)pyridin-2-yl)-N-(2-(trifluoro-methyl)-pyridin-4-yl)-1,3,5-triazin-2-amine; With N-ethyl-N,N-diisopropylamine; In 2-methyltetrahydrofuran; at 20 ℃; Inert atmosphere; Large scale;
1-Amino-2-methyl-propan-2-ol; In 2-methyltetrahydrofuran; at 20 - 30 ℃; Large scale;
Guidance literature:
With copper(l) iodide; potassium carbonate; N,N`-dimethylethylenediamine; In N,N-dimethyl-formamide; at 20 ℃; for 10h; Temperature; Solvent; Reagent/catalyst;
Guidance literature:
1-[4-oxo-6-(6-trifluoromethylpyridin-2-yl)-1,3,5-triazin-2-ylamino]-2-methyl-2-propanol; With DBN; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; In acetonitrile; at 60 ℃; for 12h; Inert atmosphere;
2-(trifluoromethyl)pyridin-4-amine; In acetonitrile; for 12h; Reagent/catalyst; Solvent; Temperature; Inert atmosphere;
Refernces Edit
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