147149-98-2

Basic information

• Product Name: 4-Amino-2-trifluoromethylpyridine
• Synonyms: 2-Ctrifluoromethyl/pyridin-4-amine;4-Amino-2-(trifluoromethyl)-pyridine;2-(Trifluoromethyl)pyridin-4-amine;2-CTRIFLUOROMETHYL/PYRIDIN-4-AMINE,98%;2-trifluoromethyl-4-aminopyridine;2-Trifluoromethyl-pyridin-4-ylamine;2-(Trifluoromethyl)pyridin-4-amine (4-Amino-2-trifluoromethylpyridine);4-Pyridinamine, 2-(trifluoromethyl)-
• CAS NO: 147149-98-2
• Molecular Formula: C₆H₅F₃N₂
• Molecular Weight: 162.12
• Product Categories: Pyridine;Fluorine series
• Mol File: 147149-98-2.mol
• Article Data: 10

Chemical Properties

• Melting Point: 58-62°C
• Boiling Point: 230.695 °C at 760 mmHg
• Flash Point: 93.321 °C
• Appearance: /
• Density: 1.369 g/cm³
• Vapor Pressure: 0.065mmHg at 25°C
• Refractive Index: 1.479
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 4.62±0.50(Predicted)
• CAS DataBase Reference: 4-Amino-2-trifluoromethylpyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Amino-2-trifluoromethylpyridine(147149-98-2)
• EPA Substance Registry System: 4-Amino-2-trifluoromethylpyridine(147149-98-2)

Safety Data

• Hazard Codes: T,Xi
• Statements: 25-36-43
• Safety Statements: 26-36/37
• RIDADR: 2811
• WGK Germany: 3
• HazardClass: 6.1
• PackingGroup: Ⅲ
• Hazardous Substances Data: 147149-98-2(Hazardous Substances Data)

Usage

General Description

4-Amino-2-trifluoromethylpyridine is a chemical compound with the molecular formula C6H5F3N2. This substance is a pyridine derivative, a class of organic compounds that feature a six-membered aromatic ring with two nitrogen atoms and four carbon atoms. The presence of the trifluoromethyl group and the amino group contribute distinct chemical properties to this compound. Its precise physical and chemical properties, including melting point, density, and solubility, depend on various factors such as temperature and pressure. 4-Amino-2-trifluoromethylpyridine could potentially be used in various applications in chemical synthesis or industrial processes, however, information about its specific uses and potential hazards is generally limited and should be sought from a relevant material safety data sheet.

InChI:InChI=1/C6H5F3N2/c7-6(8,9)5-3-4(10)1-2-11-5/h1-3H,(H2,10,11)

Upstream product

• 131748-14-6 4-chloro-2-trifluoromethylpyridine 
• 170886-13-2 4-hydroxy-2-trifluoromethylpyridine 
• 951627-69-3 4-nitro-2-(trifluoromethyl)pyridine 
• 368-48-9 2-(trifluoromethyl)pyridine 
• 147149-97-1 ⁽²⁸⁾-4-Nitro-6-trifluoromethylpyridine-N-oxide 
• 340006-62-4 (Z)-1,1,1-Trifluoro-6-methoxy-hex-5-en-3-yn-2-one 
• 22253-71-0 2-(trifluoro-methyl)pyridine 1-oxide 
• 2403-02-3 4-carboxy-2-nitropyridine N-oxide 
• 39890-95-4 2-chloro-6-trifluoromethylpyridine 

Downstream Products

• 1446502-11-9 2-methyl-1-[(4-[6-(trifluoromethyl)pyridin-2-yl]-6-{[2-(trifluoromethyl)pyridin-4-yl]amino}-1,3,5-triazin-2-yl)amino]propan-2-ol 

Relevant articles and documents

A general and versatile synthesis of 2-alkyl-4-aminopyridines

A versatile two-step synthesis of 2-alkyl-4-aminopyridines from commercially available cis-1-methoxy-1-buten-3-yne is described. Acylation of the yne derivative followed by amination and cyclization in ammonia produced the desired substituted pyridines in high yield.

PESTICIDALLY ACTIVE HETEROCYCLIC DERIVATIVES WITH SULFUR CONTAINING SUBSTITUENTS

Compounds of formula (I), wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts, stereoisomers, enantiomers, tautomers and N-oxides of those compounds, can be used as insecticides and can be prepared in a manner known per se.

CXCR3 RECEPTOR ANTAGONISTS

The present invention relates to compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R1 to R6, A, B, X, Y and n are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.