4-chloro-6-(6-(trifluoromethyl)pyridin-2-yl)-N-(2-(trifluoromethyl)pyridin-4-yl)-1,3,5-triazin-2-amine

Base Information

• Chemical Name: 4-chloro-6-(6-(trifluoromethyl)pyridin-2-yl)-N-(2-(trifluoromethyl)pyridin-4-yl)-1,3,5-triazin-2-amine
• CAS No.: 1446507-68-1
• Molecular Formula: C₁₅H₇ClF₆N₆
• Molecular Weight: 420.704
• Mol file: 1446507-68-1.mol

Synonyms:4-chloro-6-(6-(trifluoromethyl)pyridin-2-yl)-N-(2-(trifluoro-methyl)-pyridin-4-yl)-1,3,5-triazin-2-amine

Chemical Property of 4-chloro-6-(6-(trifluoromethyl)pyridin-2-yl)-N-(2-(trifluoromethyl)pyridin-4-yl)-1,3,5-triazin-2-amine

Chemical Property:

• Boiling Point: 514.5±60.0 °C(Predicted)
• PKA: 1.47±0.38(Predicted)
• Density: 1.582±0.06 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-chloro-6-(6-(trifluoromethyl)pyridin-2-yl)-N-(2-(trifluoromethyl)pyridin-4-yl)-1,3,5-triazin-2-amine

There total 9 articles about 4-chloro-6-(6-(trifluoromethyl)pyridin-2-yl)-N-(2-(trifluoromethyl)pyridin-4-yl)-1,3,5-triazin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2,4-dichloro-6-(6-(trifluoromethyl)pyridin-2-yl)-1,3,5-triazine (1446507-40-9) + 2-(trifluoromethyl)pyridin-4-amine (147149-98-2) → 4-chloro-6-(6-(trifluoromethyl)pyridin-2-yl)-N-(2-(trifluoro-methyl)-pyridin-4-yl)-1,3,5-triazin-2-amine (1446507-68-1)

Guidance literature:

In 2-methyltetrahydrofuran; at 20 - 65 ℃; for 18.5h; Inert atmosphere; Large scale;

Reference yield:

6-(trifluoromethyl)pyridine-2-carboxylic acid (131747-42-7) → 4-chloro-6-(6-(trifluoromethyl)pyridin-2-yl)-N-(2-(trifluoro-methyl)-pyridin-4-yl)-1,3,5-triazin-2-amine (1446507-68-1)

Guidance literature:

Multi-step reaction with 4 steps

1.1: thionyl chloride / 2 h / Reflux

2.1: ethanol; sodium / 0.17 h / 50 °C

2.2: 3 h / Reflux

3.1: phosphorus pentachloride / trichlorophosphate / 2 h / 100 °C

4.1: sodium hydrogencarbonate / tetrahydrofuran / 18 h / Reflux

With thionyl chloride; ethanol; phosphorus pentachloride; sodium; sodium hydrogencarbonate; In tetrahydrofuran; trichlorophosphate;

Reference yield:

6-(trifluoromethyl)pyridine-2-carboxylic acid methyl ester (155377-05-2) → 4-chloro-6-(6-(trifluoromethyl)pyridin-2-yl)-N-(2-(trifluoro-methyl)-pyridin-4-yl)-1,3,5-triazin-2-amine (1446507-68-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: ethanol; sodium / 0.17 h / 50 °C

1.2: 3 h / Reflux

2.1: phosphorus pentachloride / trichlorophosphate / 2 h / 100 °C

3.1: sodium hydrogencarbonate / tetrahydrofuran / 18 h / Reflux

With ethanol; phosphorus pentachloride; sodium; sodium hydrogencarbonate; In tetrahydrofuran; trichlorophosphate;

upstream raw materials:

2,4-dichloro-6-(6-(trifluoromethyl)pyridin-2-yl)-1,3,5-triazine

2-(trifluoromethyl)pyridin-4-amine

2-(trifluoromethyl)pyridine

6-(trifluoromethyl)pyridine-2-carboxylic acid

Downstream raw materials:

2-methyl-1-[(4-[6-(trifluoromethyl)pyridin-2-yl]-6-{[2-(trifluoromethyl)pyridin-4-yl]amino}-1,3,5-triazin-2-yl)amino]propan-2-ol

Refernces

• 1、 -. "1,3,5-TRIAZINE DERIVATIVE SALT, CRYSTAL, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF". Paragraph 0185; 0192; 0193; 0194. . Retrieved 2019/12/02.
• 2、 -. "Substituted triazine-based IDH inhibitor optical isomers and applications thereof". Paragraph 0051; 0062; 0063; 0064. . Retrieved 2019/02/17.