Spiro[piperidine-4,4'(1'H)-quinolin]-2'(3'H)-one

Base Information

• Chemical Name: Spiro[piperidine-4,4'(1'H)-quinolin]-2'(3'H)-one
• CAS No.: 159634-63-6
• Molecular Formula: C₁₃H₁₆N₂O
• Molecular Weight: 216.283
• Hs Code.: 2933990090
• Mol file: 159634-63-6.mol

Synonyms:Spiro[piperidine-4,4'(1'H)-quinolin]-2'(3'H)-one

Chemical Property of Spiro[piperidine-4,4'(1'H)-quinolin]-2'(3'H)-one

Chemical Property:

• Boiling Point: 427.9±45.0 °C(Predicted)
• PKA: 14.67±0.20(Predicted)
• PSA: 41.13000
• Density: 1.20±0.1 g/cm3(Predicted)
• LogP: 2.11680

Purity/Quality:

98% ^*data from raw suppliers

1''H-Spiro[piperidine-4,4''-quinolin]-2''(3''H)-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Spiro[piperidine-4,4'(1'H)-quinolin]-2'(3'H)-one

There total 6 articles about Spiro[piperidine-4,4'(1'H)-quinolin]-2'(3'H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl 2'-oxo-2',3'-dihydro-1'H-spiro[piperidine-4,4'-quinoline]-1-carboxylate (878167-51-2) → Spiro(2-oxo-1,2,3,4-tetrahydroquinoline-4,4'-piperidine) (159634-63-6)

Guidance literature:

With hydrogen; palladium over charcoal; In methanol; at 20 ℃; for 3h;

Reference yield:

1-(2,2,2-trifluoroacetyl)-1'H-spiro[piperidine-4,4'-quinolin]-2'(3'H)-one (159634-62-5) → Spiro(2-oxo-1,2,3,4-tetrahydroquinoline-4,4'-piperidine) (159634-63-6)

Guidance literature:

With potassium hydroxide; In methanol; water;

Reference yield:

2,3-dihydro-3-oxo-spiro[1H-indene-1,4'-piperidine]-1'-carboxylic acid 1,1-dimethylethyl ester (159634-59-0) → Spiro(2-oxo-1,2,3,4-tetrahydroquinoline-4,4'-piperidine) (159634-63-6) + 2,3-dihydro-1H-spiro[isoquinoline-4,4'-piperidin]-1-one (159634-65-8)

Guidance literature:

2,3-dihydro-3-oxo-spiro[1H-indene-1,4'-piperidine]-1'-carboxylic acid 1,1-dimethylethyl ester; With sulfuric acid; In benzene; at 20 - 40 ℃;

With hydrogen azide; In benzene; at 40 ℃;

With sulfuric acid; ammonia; more than 3 stages;

upstream raw materials:

1-(2,2,2-trifluoroacetyl)-1'H-spiro[piperidine-4,4'-quinolin]-2'(3'H)-one

benzyl 2'-oxo-2',3'-dihydro-1'H-spiro[piperidine-4,4'-quinoline]-1-carboxylate

2,3-dihydro-3-oxo-spiro[1H-indene-1,4'-piperidine]-1'-carboxylic acid 1,1-dimethylethyl ester

spiro[1H-indene-1,4'-piperidin]-3(2H)-one

Downstream raw materials:

1'-(tert-butyloxycarbonyl)spiro(tetrahydroquinol-2-one)-4'-piperidine

1'-(tert-butyloxycarbonyl)spiro(tetrahydroisoquinol-1-one)-4'-piperidine

1-neopentyl-1'-(2-nitrophenyl)-2',3'-dihydro-1'H-spiro[piperidine-4,4'-quinoline]

Refernces

• 1、 -. "SPIRO-PIPERIDINE DERIVATIVES". Page/Page column 28; 30. . Retrieved 2008/12/06.
• 2、 -. "Spiro-substituted azacycles as neurokinin antagonists". . . Retrieved 2008/06/13.