spiro[indene-1,4'-piperidin]-3(2H)-one

Base Information

Chemical Name:spiro[indene-1,4'-piperidin]-3(2H)-one
CAS No.:180465-55-8
Molecular Formula:C13H15NO
Molecular Weight:201.26400
Hs Code.:2933399090
DSSTox Substance ID:DTXSID70594128
Wikidata:Q82488869
Mol file:180465-55-8.mol

Synonyms:spiro[indene-1,4'-piperidin]-3(2H)-one;180465-55-8;Spiro[1H-indene-1,4'-piperidin]-3(2H)-one;spiro[2H-indene-3,4'-piperidine]-1-one;Spiro[indene-1,4/'-piperidin]-3(2H)-one;spiro[indane-3,4'-piperidine]-1-one;spiro[1h-indene-1,4'-piperidine]-3(2h)-one;SCHEMBL394558;DTXSID70594128;KUQPSRVEBGIYRZ-UHFFFAOYSA-N;3-oxospiro[indane-1,4'-piperidine];spiro[indane-3,4-piperidine]-1-one;AKOS015855331;SB34436;DB-001072;AM20030198;CS-0140335;spiro[indene-1,4'-piperidin]-3(2 H)-one;A15322;D71898

Suppliers and Price of spiro[indene-1,4'-piperidin]-3(2H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

J&W Pharmlab
Spiro[indene-1,4''-piperidin]-3(2H)-one 98%
5g
$ 2330.00

Crysdot
Spiro[indene-1,4'-piperidin]-3(2H)-one 95+%
5g
$ 861.00

Chemenu
Spiro[indene-1,4''-piperidin]-3(2H)-one 95%
5g
$ 805.00

American Custom Chemicals Corporation
SPIRO[INDENE-1,4'-PIPERIDIN]-3(2H)-ONE 95.00%
5MG
$ 501.66

Alichem
Spiro[indene-1,4'-piperidin]-3(2H)-one
1g
$ 400.00

Total 17 raw suppliers

Chemical Property of spiro[indene-1,4'-piperidin]-3(2H)-one

Chemical Property:

Boiling Point:362.056oC at 760 mmHg
Flash Point:151.837oC
PSA：29.10000
Density:1.168g/cm3
LogP:2.22300
XLogP3:1.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:0
Exact Mass:201.115364102
Heavy Atom Count:15
Complexity:268

Purity/Quality:

97% ^*data from raw suppliers

Spiro[indene-1,4''-piperidin]-3(2H)-one 98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CNCCC12CC(=O)C3=CC=CC=C23

Technology Process of spiro[indene-1,4'-piperidin]-3(2H)-one

There total 4 articles about spiro[indene-1,4'-piperidin]-3(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 159634-59-0
2,3-dihydro-3-oxo-spiro[1H-indene-1,4'-piperidine]-1'-carboxylic acid 1,1-dimethylethyl ester

: 180465-55-8
spiro[1H-indene-1,4'-piperidin]-3(2H)-one

Guidance literature:: 2,3-dihydro-3-oxo-spiro[1H-indene-1,4'-piperidine]-1'-carboxylic acid 1,1-dimethylethyl ester; With tetrabutylammomium bromide; water; trifluoroacetic acid; In dichloromethane; at 20 ℃; for 4h;

With water; In diethyl ether; dichloromethane;

With potassium hydroxide; In water;

Reference yield:

: 6163-66-2
2,2'-oxybis(2-methyl-propane)

: spiro[1H-indene-1,4'-piperidine]-1'-carboxylic acid

: 100-39-0
benzyl bromide

: 180465-55-8
spiro[1H-indene-1,4'-piperidin]-3(2H)-one

Guidance literature:: With potassium carbonate; In hydrogenchloride; methanol; acetonitrile;

Reference yield:

: 137419-24-0
1'-(tert-butyloxycarbonyl)spiro<1H-indene-1,4'-piperidine>

: 180465-55-8
spiro[1H-indene-1,4'-piperidin]-3(2H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) 9-NBN, 2.) PCC

2: TFA / CH₂Cl₂

With pyridinium chlorochromate; trifluoroacetic acid; In dichloromethane;
DOI:10.1016/S0960-894X(97)00075-9