Methyl 4-(2-aminoethoxy)benzoate hydrochloride

Base Information

• Chemical Name: Methyl 4-(2-aminoethoxy)benzoate hydrochloride
• CAS No.: 210113-85-2
• Molecular Formula: C₁₀H₁₃NO₃*ClH
• Molecular Weight: 0
• European Community (EC) Number: 857-731-0
• Mol file: 210113-85-2.mol

Synonyms:methyl 4-(2-aminoethoxy)benzoate hydrochloride;210113-85-2;Methyl 4-(2-aminoethoxy)benzoate HCl;methyl 4-(2-aminoethoxy)benzoate;hydrochloride;SCHEMBL442778;YKKLMHVRCUIUIT-UHFFFAOYSA-N;MFCD16617505;CS-0259293;methyl4-(2-aminoethoxy)benzoatehydrochloride;EN300-72916;F88393;Methyl 4-(2-aminoethoxyl)benzoate hydrochloride;methyl 4-(2-amino-ethoxy)benzoate hydrochloride;4-(2-aminoethoxy)benzoic acid methyl ester hydrochloride;Z1473961797;4-(2-aminoethoxyl)benzoic acid methyl ester hydrochloride

Chemical Property of Methyl 4-(2-aminoethoxy)benzoate hydrochloride

Chemical Property:

• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 231.0662210
• Heavy Atom Count: 15
• Complexity: 176

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC(=O)C1=CC=C(C=C1)OCCN.Cl

Technology Process of Methyl 4-(2-aminoethoxy)benzoate hydrochloride

There total 6 articles about Methyl 4-(2-aminoethoxy)benzoate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-(2-tert-butoxycarbonylaminoethoxy)benzoic acid methyl ester (174666-16-1) → 4-(2-Amino-ethoxy)-benzoic acid methyl ester hydrochloride salt (210113-85-2)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 20 ℃;

DOI:10.1021/acs.jmedchem.1c01155

Reference yield: 77.0%

→ 4-(2-Amino-ethoxy)-benzoic acid methyl ester hydrochloride salt (210113-85-2)

Guidance literature:

Reference yield:

2-(N-tert-butoxycarbonylamino)ethanol (26690-80-2) + methyl 4-hydroxylbenzoate (99-76-3,156291-94-0) → 4-(2-Amino-ethoxy)-benzoic acid methyl ester hydrochloride salt (210113-85-2)

Guidance literature:

2-(N-tert-butoxycarbonylamino)ethanol; methyl 4-hydroxylbenzoate; With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 20 ℃;

With acetyl chloride; In ethanol; ethyl acetate; at 40 ℃;

upstream raw materials:

2-(N-tert-butoxycarbonylamino)ethanol

methyl 4-hydroxylbenzoate

4-(2-tert-butoxycarbonylaminoethoxy)benzoic acid methyl ester

methanol

Downstream raw materials:

abexinostat