2-Bromo-5-chlorophenylboronic acid

Base Information

• Chemical Name: 2-Bromo-5-chlorophenylboronic acid
• CAS No.: 1217501-18-2
• Molecular Formula: C₆H₅BBrClO₂
• Molecular Weight: 235.272
• Hs Code.: 2931900090
• Mol file: 1217501-18-2.mol

Synonyms:2-Bromo-5-chlorophenylboronic acid

Chemical Property of 2-Bromo-5-chlorophenylboronic acid

Chemical Property:

• Boiling Point: 363.4±52.0 °C(Predicted)
• PKA: 7.28±0.58(Predicted)
• PSA: 40.46000
• Density: 1.79±0.1 g/cm3(Predicted)
• LogP: 0.78230
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Bromo-5-chlorophenylboronicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 2-Bromo-5-chlorophenylboronic acid

There total 1 articles about 2-Bromo-5-chlorophenylboronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

1-bromo-4-chloro-2-iodo-benzene (148836-41-3) + Trimethyl borate (121-43-7,63156-11-6) → (2-bromo-5-chlorophenyl)boronic acid (1217501-18-2)

Guidance literature:

1-bromo-4-chloro-2-iodo-benzene; With isopropylmagnesium bromide; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;

Trimethyl borate; In tetrahydrofuran; at -78 - 20 ℃; for 1h; Inert atmosphere;

DOI:10.1002/anie.202103625

Reference yield: 81.3%

iodobenzene (591-50-4) + (2-bromo-5-chlorophenyl)boronic acid (1217501-18-2) → 2-bromo-5-chloro-1,1'-biphenyl (1936711-65-7)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutylammomium bromide; potassium carbonate; In ethanol; water; toluene; at 75 - 80 ℃; for 12h; Inert atmosphere;

Reference yield: 65.0%

4-bromo-9,9-dimethyl-9H-fluorene (942615-32-9) + (2-bromo-5-chlorophenyl)boronic acid (1217501-18-2) → C21H16BrCl

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutylammomium bromide; potassium carbonate; In ethanol; water; toluene; at 80 ℃; for 24h; Inert atmosphere;

upstream raw materials:

1-bromo-4-chloro-2-iodo-benzene

Trimethyl borate

Downstream raw materials:

2-bromo-5-chloro-1,1'-biphenyl

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