2-(Cyclohexyloxy)acetaMide

Base Information

• Chemical Name: 2-(Cyclohexyloxy)acetaMide
• CAS No.: 98552-43-3
• Molecular Formula: C8H15NO2
• Molecular Weight: 157.213
• Hs Code.: 2924297099
• Mol file: 98552-43-3.mol

Synonyms:2-(Cyclohexyloxy)acetaMide

Chemical Property of 2-(Cyclohexyloxy)acetaMide

Chemical Property:

• Boiling Point: 300.1±25.0 °C(Predicted)
• PKA: 15.50±0.40(Predicted)
• PSA: 53.31000
• Density: 1.04±0.1 g/cm3(Predicted)
• LogP: 1.97070

Purity/Quality:

99% ^*data from raw suppliers

2-(Cyclohexyloxy)acetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(Cyclohexyloxy)acetaMide

There total 6 articles about 2-(Cyclohexyloxy)acetaMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

2-(cyclohexyloxy)acetyl chloride (191337-81-2) → 2-(cyclohexyloxy)acetamide (98552-43-3)

Guidance literature:

With ammonium hydroxide; In dichloromethane; at 20 ℃; for 0.0833333h;

Reference yield:

2-(cyclohexyloxy)ethylchloride (53067-04-2) → 2-(cyclohexyloxy)acetamide (98552-43-3)

Guidance literature:

With ammonium hydroxide; In dichloromethane; at 20 ℃; for 0.0833333h;

Reference yield:

cyclohexanol (108-93-0) → 2-(cyclohexyloxy)acetamide (98552-43-3)

Guidance literature:

Multi-step reaction with 4 steps

1: dirhodium tetraacetate / dichloromethane / 0.08 h / 20 °C

2: sodium hydroxide; water / methanol / 2 h / 20 °C

3: sulfur dichloride / 2 h / Reflux

4: ammonium hydroxide / dichloromethane / 0.08 h / 20 °C

With dirhodium tetraacetate; ammonium hydroxide; sulfur dichloride; water; sodium hydroxide; In methanol; dichloromethane;

upstream raw materials:

diazoacetic acid ethyl ester

cyclohexanol

ethyl 2-(cyclohexyloxy)acetate

2-(cyclohexyloxy)acetic acid

Refernces

• 1、 -. "Nitrogenous Heterocyclic Derivatives And Their Application In Drugs". . . Retrieved 2015/03/31.