2-(3-Bromophenyl)-1-(pyrrolidin-1-yl)ethanone

Base Information

• Chemical Name: 2-(3-Bromophenyl)-1-(pyrrolidin-1-yl)ethanone
• CAS No.: 951884-73-4
• Molecular Formula: C12H14BrNO
• Molecular Weight: 268.153
• Hs Code.: 2933990090
• Mol file: 951884-73-4.mol

Synonyms:2-(3-Bromophenyl)-1-(pyrrolidin-1-yl)ethanone;1-[(3-Bromophenyl)acetyl]pyrrolidine, 1-Bromo-3-[2-oxo-2-(pyrrolidin-1-yl)ethyl]benzene

Chemical Property of 2-(3-Bromophenyl)-1-(pyrrolidin-1-yl)ethanone

Chemical Property:

• PSA: 20.31000
• LogP: 2.55190
• Storage Temp.: 2-8°C

Purity/Quality:

≥95% ^*data from raw suppliers

2-(3-Bromophenyl)-1-(pyrrolidin-1-yl)ethanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(3-Bromophenyl)-1-(pyrrolidin-1-yl)ethanone

There total 2 articles about 2-(3-Bromophenyl)-1-(pyrrolidin-1-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

2,2-dimethylpropane-1,3-diyl [3-bromophenyl] boronate (635305-38-3) + 3-oxo-3-(pyrrolidin-1-yl)propanoic acid → 2-(3-bromophenyl)-1-(pyrrolidin-1-yl)ethanone (951884-73-4)

Guidance literature:

With copper(II) bis(trifluoromethanesulfonate); triethylamine; In N,N-dimethyl acetamide; at 20 ℃; for 70h; Sealed tube;

DOI:10.1021/jacs.6b08906

Reference yield: 29.0%

pyrrolidine (123-75-1) + 3-Bromophenylacetic acid (1878-67-7) → 2-(3-bromophenyl)-1-(pyrrolidin-1-yl)ethanone (951884-73-4)

Guidance literature:

3-Bromophenylacetic acid; With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 0.0833333h;

pyrrolidine; In N,N-dimethyl-formamide; for 18h;

Reference yield: 89.0%

2-(3-bromophenyl)-1-(pyrrolidin-1-yl)ethanone (951884-73-4) + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → (E)-methyl 3-(4-bromo-2-(2-oxo-2-(pyrrolidin-1-yl)ethyl)phenyl)acrylate

Guidance literature:

2-(3-bromophenyl)-1-(pyrrolidin-1-yl)ethanone; acrylic acid methyl ester; With 1-Adamantanecarboxylic acid; tris(acetonitrile)pentamethylcyclopentadienylrhodium(III) hexafluoroantimonate; In 1,2-dichloro-ethane; for 0.0833333h;

In 1,2-dichloro-ethane; at 100 ℃; for 12h; regioselective reaction; Sealed tube;

DOI:10.1021/acs.orglett.8b04140

upstream raw materials:

pyrrolidine

3-Bromophenylacetic acid

2,2-dimethylpropane-1,3-diyl [3-bromophenyl] boronate

Downstream raw materials:

1-(pyrrolidin-1-yl)-2-[3-(quinoxalin-6-yl)phenyl]ethanone

1-(3-bromophenethyl)pyrrolidine

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