1-Methyl-5-oxo-2-phenylpyrrolidine-3-carboxylic acid

Base Information

Chemical Name:1-Methyl-5-oxo-2-phenylpyrrolidine-3-carboxylic acid
CAS No.:461045-28-3
Molecular Formula:C₁₂H₁₃NO₃
Molecular Weight:219.24
Hs Code.:2933990090
DSSTox Substance ID:DTXSID10508481
Mol file:461045-28-3.mol

Synonyms:1-methyl-5-oxo-2-phenylpyrrolidine-3-carboxylic acid;461045-28-3;72704-31-5;MFCD07379666;Rac-(2s,3s)-1-methyl-5-oxo-2-phenyl-3-pyrrolidinecarboxylic acid;1-methyl-5-oxo-2-phenyl-3-pyrrolidinecarboxylic acid;1-Methyl-5-oxo-2-phenyl-pyrrolidine-3-carboxylic acid;SCHEMBL10685501;DTXSID10508481;OWKGDEDCXQCCSO-UHFFFAOYSA-N;AKOS005175233;NS-02599;BB 0259474;CS-0455237;FT-0655204;EN300-75650;1-Methyl-5-oxo-2-phenylpyrrolidine-3-carboxylicacid;1-methyl-5-oxo-2-phenylpyrrolidin-3-carboxylic acid;Z1182366317

Suppliers and Price of 1-Methyl-5-oxo-2-phenylpyrrolidine-3-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
1-methyl-5-oxo-2-phenylpyrrolidine-3-carboxylicAcid
50mg
$ 90.00

Matrix Scientific
1-Methyl-5-oxo-2-phenylpyrrolidine-3-carboxylic acid
500mg
$ 315.00

Crysdot
(2R,3R)-1-Methyl-5-oxo-2-phenylpyrrolidine-3-carboxylicacid 95+%
1g
$ 473.00

Alichem
(2R,3R)-1-Methyl-5-oxo-2-phenylpyrrolidine-3-carboxylicacid
1g
$ 487.56

AK Scientific
1-Methyl-5-oxo-2-phenylpyrrolidine-3-carboxylicacid
500mg
$ 475.00

Total 9 raw suppliers

Chemical Property of 1-Methyl-5-oxo-2-phenylpyrrolidine-3-carboxylic acid

Chemical Property:

PSA：57.61000
LogP:1.22850
Storage Temp.:2-8°C
XLogP3:0.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:219.08954328
Heavy Atom Count:16
Complexity:297

Purity/Quality:

97% ^*data from raw suppliers

1-methyl-5-oxo-2-phenylpyrrolidine-3-carboxylicAcid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1C(C(CC1=O)C(=O)O)C2=CC=CC=C2

Technology Process of 1-Methyl-5-oxo-2-phenylpyrrolidine-3-carboxylic acid

There total 6 articles about 1-Methyl-5-oxo-2-phenylpyrrolidine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 108-30-5
succinic acid anhydride

: 622-29-7
N-Benzylidenemethylamine

: 20178-20-5,20178-21-6,72704-31-5,461045-28-3
(+/-)-(2R,3R)-1-methyl-5-oxo-2-phenyltetrahydro-1H-pyrrolidine-3-carboxylic acid

Guidance literature:: In 5,5-dimethyl-1,3-cyclohexadiene; for 6h; Reflux;
DOI:10.1021/co4001277

Reference yield: 43.0%

: 108-30-5
succinic acid anhydride

: 25521-74-8
N-benzylidenemethylamine

: 20178-20-5,20178-21-6,72704-31-5,461045-28-3
(+/-)-(2R,3R)-1-methyl-5-oxo-2-phenyltetrahydro-1H-pyrrolidine-3-carboxylic acid

Guidance literature:: In benzene; for 28h; Heating;
DOI:10.1016/j.tetasy.2008.01.014

Reference yield: 28.0%

: 20178-20-5,20178-21-6,72704-31-5,461045-28-3
(+/-)-(2R,3R)-1-methyl-5-oxo-2-phenyltetrahydro-1H-pyrrolidine-3-carboxylic acid

: 883111-37-3,461045-28-3
(2S,3S)-1-methyl-5-oxo-2-phenyltetrahydro-1H-pyrrolidine-3-carboxylic acid

: 461045-28-3
(2S,3S)-1-methyl-5-oxo-2-phenyltetrahydro-1H-pyrrolidine-3-carboxylic acid

Guidance literature:: (+/-)-(2R,3R)-1-methyl-5-oxo-2-phenyltetrahydro-1H-pyrrolidine-3-carboxylic acid; In propan-1-ol; for 0.0833333h; Heating;

With sodium hydroxide; In dichloromethane; Further stages.;
DOI:10.1016/j.tetasy.2008.01.014