L-Phe(3-OH)-OMe.Hcl

Base Information

• Chemical Name: L-Phe(3-OH)-OMe.Hcl
• CAS No.: 34260-72-5
• Molecular Formula: C₁₀H₁₃NO₃*ClH
• Molecular Weight: 231.679
• Hs Code.: 2922509090
• Mol file: 34260-72-5.mol

Synonyms:L-Phe(3-OH)-OMe.Hcl;(S)-Methyl 2-aMino-3-(3-hydroxyphenyl)propanoate hydrochloride

Chemical Property of L-Phe(3-OH)-OMe.Hcl

Chemical Property:

• PSA: 72.55000
• LogP: 1.93730
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

(S)-Methyl2-Amino-3-(3-hydroxyphenyl)propanoateHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (S)-Methyl 2-amino-3-(3-hydroxyphenyl)propanoate Hydrochloride is a useful intermediate in the preparation of tert-butoxy substituted Fmoc-L-phenylalanine (L-tyrosine analog).

Technology Process of L-Phe(3-OH)-OMe.Hcl

There total 5 articles about L-Phe(3-OH)-OMe.Hcl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

m-tyrosine (587-33-7,775-06-4,2180-37-2,32140-49-1,29562-33-2) → methyl (2S)-2-amino-3-(3-hydroxyphenyl)propanoate hydrochloride (34260-70-3,34260-72-5,72683-79-5)

Guidance literature:

With thionyl chloride; In methanol; at 0 - 90 ℃; for 6h;

Reference yield: 99.0%

methanol (67-56-1) + m-tyrosine (587-33-7,775-06-4,2180-37-2,32140-49-1,29562-33-2) → methyl (2S)-2-amino-3-(3-hydroxyphenyl)propanoate hydrochloride (34260-70-3,34260-72-5,72683-79-5)

Guidance literature:

With acetyl chloride; Ambient temperature;

DOI:10.1055/s-1999-3119

Reference yield:

methanol (67-56-1) + N-formyl-L-m-hydroxyphenylalanine (72683-77-3) → methyl (2S)-2-amino-3-(3-hydroxyphenyl)propanoate hydrochloride (34260-70-3,34260-72-5,72683-79-5)

Guidance literature:

With hydrogenchloride; Yield given. Multistep reaction; 1.) 100 deg C, 4 h;

DOI:10.1021/jm00178a013

upstream raw materials:

methanol

N-formyl-L-m-hydroxyphenylalanine

m-tyrosine

D/L-3-hydroxy-phenylalanine

Downstream raw materials:

4-(9H-fluoren-9-ylmethoxycarbonylamino)-4-[2-(3-hydroxy-phenyl)-1-methoxycarbonyl-ethylcarbamoyl]-butyric acid tert-butyl ester

[S,S]-2-(2-tert-butoxycarbonylamino-2-cyclohexylacetylamino)-3-(3-hydroxyphenyl)propionic acid methyl ester

methyl [12S,9S]-[12-cyclohexyl-11,14-dioxo-2-oxa-10,13-diazatricyclo[15.2.2.1^3,7]docosa-1⁽²⁰⁾,3⁽²²⁾,4,6,17⁽²¹⁾,18-hexaene-9-carboxylate]

(9S,12S)-12-Cyclohexyl-11,14-dioxo-2-oxa-10,13-diaza-tricyclo[15.2.2.1^3,7]docosa-1⁽²⁰⁾,3,5,7⁽²²⁾,17⁽²¹⁾,18-hexaene-9-carboxylic acid