2-Fluoro-4-(trifluoromethoxy)aniline

Base Information

Chemical Name:2-Fluoro-4-(trifluoromethoxy)aniline
CAS No.:123572-58-7
Molecular Formula:C7H5F4NO
Molecular Weight:195.116
Hs Code.:2922299090
European Community (EC) Number:688-952-9
Mol file:123572-58-7.mol

Synonyms:2-fluoro-4-(trifluoromethoxy)aniline;123572-58-7;Benzenamine, 2-fluoro-4-(trifluoromethoxy)-;2-Fluoro-4-(trifluoroMethoxy)aniline, 97per cent;MFCD15527448;SCHEMBL519232;YEA57258;2-fluro-4-(trifluoromethoxy)aniline;AC8037;AKOS015957048;CS-W010630;JS-4926;SY029690;2-Fluoro-4-(trifluoroMethoxy)aniline, 97%;EN300-86197;A890675

Suppliers and Price of 2-Fluoro-4-(trifluoromethoxy)aniline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

SynQuest Laboratories
2-Fluoro-4-(trifluoromethoxy)aniline
5 g
$ 768.00

SynQuest Laboratories
2-Fluoro-4-(trifluoromethoxy)aniline
1 g
$ 192.00

Oakwood
2-Fluoro-4-(trifluoromethoxy)aniline
250mg
$ 126.00

Matrix Scientific
2-Fluoro-4-(trifluoromethoxy)aniline
1g
$ 310.00

Matrix Scientific
2-Fluoro-4-(trifluoromethoxy)aniline
5g
$ 1240.00

Labseeker
2-fluoro-4-(trifluoromethoxy)benzenamine 95
5g
$ 3208.00

Crysdot
2-Fluoro-4-(trifluoromethoxy)aniline 95+%
1g
$ 465.00

ChemScene
2-Fluoro-4-(trifluoromethoxy)aniline
1g
$ 201.00

ChemScene
2-Fluoro-4-(trifluoromethoxy)aniline
5g
$ 802.00

Chemenu
2-fluoro-4-(trifluoromethoxy)aniline 95+%
25g
$ 3906.00

Total 10 raw suppliers

Chemical Property of 2-Fluoro-4-(trifluoromethoxy)aniline

Chemical Property:

Boiling Point:161.4±35.0 °C(Predicted)
PKA:2.35±0.10(Predicted)
PSA：35.25000
Density:1.431±0.06 g/cm3(Predicted)
LogP:2.88770
XLogP3:2.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:1
Exact Mass:195.03072643
Heavy Atom Count:13
Complexity:172

Purity/Quality:

97% ^*data from raw suppliers

2-Fluoro-4-(trifluoromethoxy)aniline ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=C(C=C1OC(F)(F)F)F)N

Technology Process of 2-Fluoro-4-(trifluoromethoxy)aniline

There total 5 articles about 2-Fluoro-4-(trifluoromethoxy)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 168971-68-4
1-bromo-2-fluoro-4-(trifluoromethoxy)benzene

: 123572-58-7
2-fluoro-4-(trifluoromethoxy)aniline

Guidance literature:: 1-bromo-2-fluoro-4-(trifluoromethoxy)benzene; With Benzophenone imine; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 100 ℃; for 5h; Inert atmosphere;

With hydrogenchloride; water; In tetrahydrofuran; at 10 - 35 ℃; for 1h;

With sodium hydroxide; In tetrahydrofuran; water;

Reference yield:

: 123572-64-5
2-fluoro-1-nitro-4-(trifluoromethoxy) benzene

: 123572-58-7
2-fluoro-4-(trifluoromethoxy)aniline

Guidance literature:: With palladium on activated charcoal; hydrogen; In methanol; at 20 - 30 ℃;

Reference yield:

: 4,4′-bis(trifluoromethoxy)azobenzene

: 123572-58-7
2-fluoro-4-(trifluoromethoxy)aniline

Guidance literature:: Multi-step reaction with 2 steps

1: bis(dibenzylideneacetone)-palladium⁽⁰⁾; N-fluorobis(benzenesulfon)imide; potassium nitrate / ethyl acetate / 12 h / 75 °C / Sealed tube

2: sodium tetrahydroborate; copper(l) chloride / ethanol / Reflux

With sodium tetrahydroborate; N-fluorobis(benzenesulfon)imide; potassium nitrate; copper(l) chloride; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In ethanol; ethyl acetate;
DOI:10.1039/c9cc07726j