1-Bromo-2-fluoro-4-(trifluoromethoxy)benzene

Base Information

• Chemical Name: 1-Bromo-2-fluoro-4-(trifluoromethoxy)benzene
• CAS No.: 168971-68-4
• Molecular Formula: C7H3BrF4O
• Molecular Weight: 258.998
• Hs Code.: 2909309090
• Mol file: 168971-68-4.mol

Synonyms:1-Bromo-2-fluoro-4-(trifluoromethoxy)benzene;4-Bromo-3-fluoro-1-(trifluoromethoxy)benzene;benzene, 1-bromo-2-fluoro-4-(trifluoromethoxy)-;

Chemical Property of 1-Bromo-2-fluoro-4-(trifluoromethoxy)benzene

Chemical Property:

• Boiling Point: 158.457 °C at 760 mmHg
• Flash Point: 60.565 °C
• PSA: 9.23000
• Density: 1.724g/cm³
• LogP: 3.48680
• Storage Temp.: Room temperature.

Purity/Quality:

99% ^*data from raw suppliers

1-Bromo-2-fluoro-4-(trifluoromethoxy)benzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Bromo-2-fluoro-4-(trifluoromethoxy)benzene

There total 3 articles about 1-Bromo-2-fluoro-4-(trifluoromethoxy)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-fluoro-4-(trifluoromethoxy)aniline (123572-58-7) → 1-bromo-2-fluoro-4-(trifluoromethoxy)benzene (168971-68-4)

Guidance literature:

With tert.-butylnitrite; copper(I) bromide; In acetonitrile; at 60 ℃; for 0.5h; Inert atmosphere;

Reference yield:

2-fluoro-1-nitro-4-(trifluoromethoxy) benzene (123572-64-5) → 1-bromo-2-fluoro-4-(trifluoromethoxy)benzene (168971-68-4)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium on activated charcoal; hydrogen / methanol / 20 - 30 °C

2: tert.-butylnitrite; copper(I) bromide / acetonitrile / 0.5 h / 60 °C / Inert atmosphere

With tert.-butylnitrite; palladium on activated charcoal; hydrogen; copper(I) bromide; In methanol; acetonitrile;

Reference yield:

meta-fluoro(trifluoromethoxy)benzene (1077-01-6) → 1-bromo-2-fluoro-4-(trifluoromethoxy)benzene (168971-68-4)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium nitrate; sulfuric acid / 30 °C / Cooling with ice; Inert atmosphere

2: palladium on activated charcoal; hydrogen / methanol / 20 - 30 °C

3: tert.-butylnitrite; copper(I) bromide / acetonitrile / 0.5 h / 60 °C / Inert atmosphere

With tert.-butylnitrite; sulfuric acid; palladium on activated charcoal; hydrogen; potassium nitrate; copper(I) bromide; In methanol; acetonitrile;

upstream raw materials:

2-fluoro-1-nitro-4-(trifluoromethoxy) benzene

meta-fluoro(trifluoromethoxy)benzene

2-fluoro-4-(trifluoromethoxy)aniline

Downstream raw materials:

2-(2-fluoro-4-(trifluoromethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

(2-fluoro-4-(trifluoromethoxy)phenyl)boronic acid

2-fluoro-4-(trifluoromethoxy) phenol

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