N2-Isobutyryl-2'-O-Methyl-guanosine

Base Information

• Chemical Name: N2-Isobutyryl-2'-O-Methyl-guanosine
• CAS No.: 63264-29-9
• Molecular Formula: C15H21N5O5
• Molecular Weight: 367.35714
• Mol file: 63264-29-9.mol

Synonyms:N2-Isobutyryl-2'-O-Methyl-guanosine;iBu-2'-OMe-G;Guanosine, 2'-O-Methyl-N-(2-Methyl-1-oxopropyl)-;2'-O-Methyl-N2-isobutyroylguanosine

Chemical Property of N2-Isobutyryl-2'-O-Methyl-guanosine

Chemical Property:

• PKA: 9.16±0.20(Predicted)
• PSA: 151.59000
• Density: 1.68±0.1 g/cm3(Predicted)
• LogP: -0.94730

Purity/Quality:

98%, ^*data from raw suppliers

N2-Isobutyryl-2'-O-methylguanosine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N2-Isobutyryl-2'-O-Methyl-guanosine

There total 18 articles about N2-Isobutyryl-2'-O-Methyl-guanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

→ N2-isobutyryl-2′-O-methylguanosine (63264-29-9)

Guidance literature:

Reference yield: 90.0%

N2-isobutyryl-O6-[(2-trimethylsilyl)-ethyl]-2'-O-methyl-3',5'-O-di-tert-butylsilanediyl guanosine (958638-85-2) → N2-isobutyryl-2′-O-methylguanosine (63264-29-9)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 1h;

DOI:10.1016/j.tet.2007.08.006

Reference yield: 67.0%

2'-O-methylguanosine (2140-71-8) + 2-Methylpropionic anhydride (97-72-3) → N2-isobutyryl-2′-O-methylguanosine (63264-29-9)

Guidance literature:

2'-O-methylguanosine; With pyridine; chloro-trimethyl-silane; for 0.5h;

2-Methylpropionic anhydride; at 20 ℃; for 3h;

DOI:10.3390/molecules23102572

upstream raw materials:

2-N-Isobutyryl-2'-O-methyl-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)guanosine

N²-isobutyryl-O⁶-[(2-trimethylsilyl)-ethyl]-2'-O-methyl-3',5'-O-di-tert-butylsilanediyl guanosine

O⁶-[(2-trimethylsilyl)-ethyl]-3',5'-O-di-tert-butylsilanediyl guanosine

O⁶-[(2-trimethylsilyl)-ethyl]-2'-O-methyl-3',5'-O-di-tert-butylsilanediyl guanosine

Downstream raw materials:

N-(9-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxy-3-methoxytetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide

N-(9-{(2R,3R,4R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-formyl-3-methoxy-tetrahydro-furan-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-isobutyramide

Thiocarbonic acid O-[(2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-4-methoxy-tetrahydro-furan-3-yl] ester O-(3-tert-butyl-phenyl) ester

5'-O-(tert-butyl)diphenylsilyl-2'-O-methyl-N²-isobutyrylguanosine

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