6-Methyl-8-methylsulfanyl-imidazo[1,2-a]pyrazine

Base Information

• Chemical Name: 6-Methyl-8-methylsulfanyl-imidazo[1,2-a]pyrazine
• CAS No.: 1094070-46-8
• Molecular Formula: C₈H₉N₃S
• Molecular Weight: 179.246
• Hs Code.: 2933990090
• Mol file: 1094070-46-8.mol

Synonyms:6-Methyl-8-methylsulfanyl-imidazo[1,2-a]pyrazine;6-Methyl-8-(Methylthio)iMidazo[1,2-a]pyrazine;Imidazo[1,2-a]pyrazine, 6-methyl-8-(methylthio)-

Chemical Property of 6-Methyl-8-methylsulfanyl-imidazo[1,2-a]pyrazine

Chemical Property:

• PKA: 3.47±0.30(Predicted)
• PSA: 55.49000
• Density: 1.30±0.1 g/cm3(Predicted)
• LogP: 1.75960
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

6-Methyl-8-methylsulfanyl-imidazo[1,2-a]pyrazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-Methyl-8-methylsulfanyl-imidazo[1,2-a]pyrazine

There total 4 articles about 6-Methyl-8-methylsulfanyl-imidazo[1,2-a]pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

6-bromo-3-iodo-8-methylsulfanyl-imidazo[1,2-a]pyrazine (936360-80-4) + Trimethylboroxine (823-96-1) → C8H9N3S (1094070-46-8)

Guidance literature:

With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 105 ℃;

Reference yield: 63.0%

6-bromo-8-methylsulfanyl-imidazo[1,2-a]pyrazine (887475-71-0) + Trimethylboroxine (823-96-1) → C8H9N3S (1094070-46-8)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃;

DOI:10.1016/j.bmcl.2012.03.051

Reference yield:

6-bromo-8-methylsulfanyl-imidazo[1,2-a]pyrazine (887475-71-0) → C8H9N3S (1094070-46-8)

Guidance literature:

Multi-step reaction with 2 steps

1: N-iodo-succinimide / N,N-dimethyl-formamide / 16 h / 60 °C

2: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 105 °C

With N-iodo-succinimide; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide;

upstream raw materials:

6-bromo-3-iodo-8-methylsulfanyl-imidazo[1,2-a]pyrazine

Trimethylboroxine

6-bromo-8-methylsulfanyl-imidazo[1,2-a]pyrazine

6,8-dibromoimidazo[1,2-a]pyrazine

Downstream raw materials:

C₁₇H₁₃ClN₆O₂

C₂₁H₂₁ClN₈O

C₃₀H₃₅N₉O₂S

C₃₀H₃₅N₉O₂S

Refernces

• 1、 Zeng, Hongbo,Belanger, David B.,Curran, Patrick J.,Shipps Jr., Gerald W.,Miao, Hua,Bracken, Jack B.,Arshad Siddiqui,Malkowski, Michael,Wang, Yan. "Discovery of novel imidazo[1,2-a]pyrazin-8-amines as Brk/PTK6 inhibitors". scheme or table. p. 5870 - 5875. Retrieved 2011/10/09.
• 2、 -. "IMIDAZOPYRAZINES AS PROTEIN KINASE INHIBITORS". Page/Page column 72; 73. . Retrieved 2009/01/23.