936360-80-4

Basic information

• Product Name: 6-BroMo-3-iodo-8-Methylsulfanyl-iMidazo[1,2-a]pyrazine
• Synonyms: 6-BroMo-3-iodo-8-Methylsulfanyl-iMidazo[1,2-a]pyrazine;6-Bromo-3-iodo-8-(methylthio)imidazo[1,2-a]pyrazine
• CAS NO: 936360-80-4
• Molecular Formula: C₇H₅BrIN₃S
• Molecular Weight: 370.00817
• Mol File: 936360-80-4.mol
• Article Data: 16

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 6-BroMo-3-iodo-8-Methylsulfanyl-iMidazo[1,2-a]pyrazine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-BroMo-3-iodo-8-Methylsulfanyl-iMidazo[1,2-a]pyrazine(936360-80-4)
• EPA Substance Registry System: 6-BroMo-3-iodo-8-Methylsulfanyl-iMidazo[1,2-a]pyrazine(936360-80-4)

Safety Data

• Hazardous Substances Data: 936360-80-4(Hazardous Substances Data)

Upstream product

• 63744-22-9 6,8-dibromoimidazo[1,2-a]pyrazine 
• 887475-71-0 6-bromo-8-methylsulfanyl-imidazo[1,2-a]pyrazine 

Downstream Products

• 1334423-23-2 N-cyclopropyl-4-(8-methylsulfanyl-6-phenyl-imidazo[1,2-a]pyrazin-3-yl)-benzamide 
• 1334423-24-3 N-cyclopropyl-4-(8-methylsulfonyl-6-phenyl-imidazo[1,2-a]pyrazin-3-yl)-benzamide 
• 1334423-25-4 N-cyclopropyl-4-[8-(methylsulfinyl)-6-phenylimidazo[1,2-a]pyrazin-3-yl]benzamide 
• 1334423-26-5 N-cyclopropyl-4-[8-(ethylsulfanyl)-6-phenylimidazo[1,2-a]pyrazin-3-yl]benzamide 
• 1334423-27-6 N-cyclopropyl-4-[8-(ethylsulfinyl)-6-phenylimidazo[1,2-a]pyrazin-3-yl]benzamide 
• 1334423-28-7 N-cyclopropyl-4-[8-(ethylsulfonyl)-6-phenylimidazo[1,2-a]pyrazin-3-yl]benzamide 
• 1334423-42-5 N-cyclopropyl-4-{8-[S-methyl-N-(trifluoroacetyl)sulfonimidoyl]-6-phenylimidazo[1,2-a]pyrazin-3-yl}benzamide 
• 1334423-43-6 tert-butyl [2-({3-[4-(cyclopropylcarbamoyl)phenyl]-6-phenylimidazo[1,2-a]pyrazin-8-yl}sulfanyl)ethyl]carbamate 
• 1334423-74-3 4-{8-[(2-aminoethyl)sulfanyl]-6-phenylimidazo[1,2-a]pyrazin-3-yl}-N-cyclopropylbenzamide 
• 1263425-46-2 4-(6-bromo-8-methylsulfanyl-imidazo[1,2-a]pyrazin-3-yl)-N-cyclopropyl-benzamide 
• 1382479-89-1 4-{8-[(Cyclohexylmethyl)amino]-6-phenylimidazo[1,2-a]pyrazin-3-yl}-N-cyclopropylbenzamide 
• 1382479-07-3 N-cyclopropyl-4-{8-[(2-hydroxyethyl)amino]-6-phenylimidazo[1,2-a]pyrazin-3-yl}benzamide 
• 1383119-93-4 N-cyclopropyl-4-{6-(3-hydroxy-3-methylbutyl)-8-[(2-methylpropyl)amino]imidazo[1,2-a]pyrazin-3-yl}benzamide 
• 1383119-64-9 4-[8-(allylamino)-6-phenylimidazo[1,2-a]pyrazin-3-yl]-N-cyclopropylbenzamide 

Relevant articles and documents

COMBINATIONS FOR THE TREATMENT OF CANCER

The present invention relates to combinations of at least two compounds A and B, compound A being an inhibitor of Mps-1 kinase, and compound B being an inhibitor of an anti-apoptotic protein of the Bcl-2 family. Another aspect of the present invention relates to the use of such combinations as described supra for the preparation of a medicament for the treatment or prophylaxis of a disease, particularly for the treatment of cancer. Another aspect of the present invention relates to the use of an anti- apoptotic protein from the Bcl-2 family as a sensitizer of cells to Mps-1 inhibitors. Another aspect of the present invention relates to the use of the ratio of pro-apoptotic and anti-apoptotic proteins from the Bcl-2 family in a biological sample as a biomarker for a Mps-1 kinase inhibitor treatment.

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