4-[(DiMethylaMino)Methyl]-benzoic acid HCl

Base Information

• Chemical Name: 4-[(DiMethylaMino)Methyl]-benzoic acid HCl
• CAS No.: 17847-26-6
• Molecular Formula: C10H14ClNO2
• Molecular Weight: 215.67666
• Hs Code.: 2922498590
• Mol file: 17847-26-6.mol

Synonyms:4-[(DiMethylaMino)Methyl]-benzoic acid HCl;Benzoic acid, 4-[(diMethylaMino)Methyl]-, hydrochloride

Chemical Property of 4-[(DiMethylaMino)Methyl]-benzoic acid HCl

Chemical Property:

• PSA: 40.54000
• LogP: 2.24840
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

4-((Dimethylamino)methyl)benzoicAcidHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[(DiMethylaMino)Methyl]-benzoic acid HCl

There total 3 articles about 4-[(DiMethylaMino)Methyl]-benzoic acid HCl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

methyl 4-(N,N-dimethylaminomethyl)benzoate (18153-53-2) → 4-[(dimethylamino)methyl]benzoic acid hydrochloride (17847-26-6)

Guidance literature:

With hydrogenchloride; In water; at 100 ℃;

DOI:10.1039/c9cc01939a

Reference yield:

Methyl 4-(bromomethyl)benzoate (2417-72-3) → 4-[(dimethylamino)methyl]benzoic acid hydrochloride (17847-26-6)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate; potassium iodide / ethanol / Inert atmosphere

2: hydrogenchloride; water

With hydrogenchloride; water; potassium carbonate; potassium iodide; In ethanol;

DOI:10.1016/j.bmc.2011.08.001

Reference yield:

4-methyl-benzoic acid methyl ester (99-75-2) → 4-[(dimethylamino)methyl]benzoic acid hydrochloride (17847-26-6)

Guidance literature:

Multi-step reaction with 3 steps

1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 12 h / Reflux; Inert atmosphere

2: potassium carbonate; potassium iodide / ethanol / Inert atmosphere

3: hydrogenchloride; water

With hydrogenchloride; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); water; potassium carbonate; potassium iodide; In tetrachloromethane; ethanol;

DOI:10.1016/j.bmc.2011.08.001

upstream raw materials:

4-methyl-benzoic acid methyl ester

Methyl 4-(bromomethyl)benzoate

methyl 4-(N,N-dimethylaminomethyl)benzoate

Refernces

• 1、 Qiu, Jingying,Xu, Bixue,Huang, Zhengming,Pan, Weidong,Cao, Peixue,Liu, Changxiao,Hao, Xiaojiang,Song, Baoan,Liang, Guangyi. "Synthesis and biological evaluation of Matijing-Su derivatives as potent anti-HBV agents". . p. 5352 - 5360. Retrieved 2011/10/12.